PMID- 7926911
OWN - NLM
STAT- MEDLINE
DCOM- 19941102
LR  - 20190501
IS  - 0017-5749 (Print)
IS  - 1458-3288 (Electronic)
IS  - 0017-5749 (Linking)
VI  - 35
IP  - 8
DP  - 1994 Aug
TI  - Immunoelectron microscopic localisation of transforming growth factor alpha in 
      rat colon.
PG  - 1086-9
AB  - Transforming growth factor alpha (TGF alpha) is a polypeptide, which binds to the 
      epidermal growth factor receptor to carry out its function related to cell 
      proliferation and differentiation. The ultrastructural localisation of TGF alpha 
      was studied in both the proximal and the distal colon. The columnar cells, lining 
      the surface epithelium of the proximal colon, showed a strong immunoreactivity in 
      the polyribosomes and in the interdigitations of the lateral membrane. The 
      columnar cells of the crypts and the goblet cells in both the proximal and the 
      distal colon showed the immunostaining in the cis and trans cisternae of the 
      Golgi apparatus. TGF alpha seems to be processed differently in the surface 
      columnar cells and in the crypt columnar cells and goblet cells. Moreover, it 
      probably has different roles in proliferation and differentiation.
FAU - Perez-Tomas, R
AU  - Perez-Tomas R
AD  - Department of Cellular Biology and Anatomical Pathology, Faculty of Medicine, 
      University of Barcelona, Spain.
FAU - Cullere, X
AU  - Cullere X
FAU - Asbert, M
AU  - Asbert M
FAU - Diaz-Ruiz, C
AU  - Diaz-Ruiz C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Gut
JT  - Gut
JID - 2985108R
RN  - 0 (Transforming Growth Factor alpha)
SB  - IM
MH  - Animals
MH  - Colon/*chemistry/ultrastructure
MH  - Cytoplasm/chemistry
MH  - Golgi Apparatus/chemistry
MH  - Intracellular Membranes/chemistry
MH  - Microscopy, Immunoelectron
MH  - Polyribosomes/chemistry
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Transforming Growth Factor alpha/*analysis
PMC - PMC1375060
EDAT- 1994/08/01 00:00
MHDA- 1994/08/01 00:01
PMCR- 1994/08/01
CRDT- 1994/08/01 00:00
PHST- 1994/08/01 00:00 [pubmed]
PHST- 1994/08/01 00:01 [medline]
PHST- 1994/08/01 00:00 [entrez]
PHST- 1994/08/01 00:00 [pmc-release]
AID - 10.1136/gut.35.8.1086 [doi]
PST - ppublish
SO  - Gut. 1994 Aug;35(8):1086-9. doi: 10.1136/gut.35.8.1086.