PMID- 7930702
OWN - NLM
STAT- MEDLINE
DCOM- 19941101
LR  - 20190512
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 170
IP  - 4
DP  - 1994 Oct
TI  - Immunoregulatory and proinflammatory cytokine production in visceral and 
      cutaneous leishmaniasis.
PG  - 1037-40
AB  - Visceral leishmaniasis (VL) and cutaneous leishmaniasis (CL) are the major 
      parasitic diseases in which the immune system is implicated in pathogenesis. The 
      in vitro production of interleukin (IL)-2, IL-4, IL-6, IL-8, tumor necrosis 
      factor-alpha (TNF alpha), and granulocyte-macrophage colony-stimulating factor 
      (GM-CSF), spontaneously and in response to stimulation of peripheral blood 
      mononuclear cells with anti-CD3, phytohemagglutinin, and lipopolysaccharide, was 
      investigated to determine their importance in VL and CL. Highly enhanced 
      production of IL-4, IL-6, IL-8, and TNF alpha was seen in VL. However, enhanced 
      production of IL-4 and TNF alpha but almost normal production of IL-6 and IL-8 
      was seen in CL. The highly increased IL-4 production was the most characteristic 
      and common feature of both VL and CL. Of interest, highly deficient GM-CSF 
      production may be implicated in abnormalities in synthesis of hematopoietic 
      lineage of cells in these diseases.
FAU - Raziuddin, S
AU  - Raziuddin S
AD  - Department of Clinical Immunology, King Saud University, College of Medicine, 
      Abha, Saudi Arabia.
FAU - Abdalla, R E
AU  - Abdalla RE
FAU - el-Awad, E H
AU  - el-Awad EH
FAU - al-Janadi, M
AU  - al-Janadi M
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Controlled Clinical Trial
PT  - Journal Article
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (Cytokines)
RN  - 0 (Interleukins)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 83869-56-1 (Granulocyte-Macrophage Colony-Stimulating Factor)
SB  - IM
MH  - Cells, Cultured
MH  - Child
MH  - Child, Preschool
MH  - Cytokines/*biosynthesis
MH  - Female
MH  - Granulocyte-Macrophage Colony-Stimulating Factor/biosynthesis
MH  - Humans
MH  - Interleukins/biosynthesis
MH  - Leishmaniasis, Cutaneous/*immunology
MH  - Leishmaniasis, Visceral/*immunology
MH  - Lipopolysaccharides/pharmacology
MH  - *Lymphocyte Activation
MH  - Lymphocytes/drug effects/*immunology
MH  - Male
MH  - Reference Values
MH  - Tumor Necrosis Factor-alpha/biosynthesis
EDAT- 1994/10/01 00:00
MHDA- 1994/10/01 00:01
CRDT- 1994/10/01 00:00
PHST- 1994/10/01 00:00 [pubmed]
PHST- 1994/10/01 00:01 [medline]
PHST- 1994/10/01 00:00 [entrez]
AID - 10.1093/infdis/170.4.1037 [doi]
PST - ppublish
SO  - J Infect Dis. 1994 Oct;170(4):1037-40. doi: 10.1093/infdis/170.4.1037.