PMID- 7934616
OWN - NLM
STAT- MEDLINE
DCOM- 19941025
LR  - 20190701
IS  - 0024-3205 (Print)
IS  - 0024-3205 (Linking)
VI  - 55
IP  - 15
DP  - 1994
TI  - Attenuation of 3,4-methylenedioxymethamphetamine (MDMA) induced neurotoxicity 
      with the serotonin precursors tryptophan and 5-hydroxytryptophan.
PG  - 1193-8
AB  - Treatment of rats with serotonin (5-HT) precursors tryptophan (TRP, 400 mg/kg) 
      and 5-hydroxytryptophan (5-HTP, 50 mg/kg) was shown to attenuate MDMA (20 mg/kg) 
      induced serotonergic neurotoxicity as measured by [3H]-paroxetine binding in the 
      striatum, hippocampus, and frontal cortex of the rat brain. Hippocampal 5-HT and 
      5-HIAA levels were also indicative of the protective effects of TRP and 5-HTP. 
      These results suggest that depletion of 5-HT stores is important for MDMA-induced 
      neurotoxicity. The possible significance of this 5-HT depletion in MDMA-induced 
      serotonergic terminal degeneration is also discussed.
FAU - Sprague, J E
AU  - Sprague JE
AD  - Department of Pharmacology and Toxicology, School of Pharmacy and Pharmacal 
      Sciences, Purdue University, West Lafayette, IN 47907.
FAU - Huang, X
AU  - Huang X
FAU - Kanthasamy, A
AU  - Kanthasamy A
FAU - Nichols, D E
AU  - Nichols DE
LA  - eng
GR  - DA04758/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
RN  - 333DO1RDJY (Serotonin)
RN  - 8DUH1N11BX (Tryptophan)
RN  - C1LJO185Q9 (5-Hydroxytryptophan)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - 5-Hydroxytryptophan/*pharmacology
MH  - Animals
MH  - Brain Diseases/*chemically induced/metabolism/prevention & control
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*antagonists & inhibitors/toxicity
MH  - Nerve Endings/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Serotonin/metabolism
MH  - Tryptophan/*pharmacology
EDAT- 1994/01/01 00:00
MHDA- 1994/01/01 00:01
CRDT- 1994/01/01 00:00
PHST- 1994/01/01 00:00 [pubmed]
PHST- 1994/01/01 00:01 [medline]
PHST- 1994/01/01 00:00 [entrez]
AID - 0024-3205(94)00658-X [pii]
AID - 10.1016/0024-3205(94)00658-x [doi]
PST - ppublish
SO  - Life Sci. 1994;55(15):1193-8. doi: 10.1016/0024-3205(94)00658-x.