PMID- 7939136
OWN - NLM
STAT- MEDLINE
DCOM- 19941122
LR  - 20191023
IS  - 0172-8172 (Print)
IS  - 0172-8172 (Linking)
VI  - 14
IP  - 1
DP  - 1994
TI  - Interleukin-4 (IL-4) induces down-modulation and shedding of the p55 tumour 
      necrosis factor receptor and inhibits TNF alpha's effect on rheumatoid synovial 
      fibroblasts.
PG  - 21-5
AB  - Recombinant human interleukin-4 (rhIL-4) and rhIL-1 alpha each produced a rapid 
      down-modulation of tumour necrosis factor receptor (TNFR) on rheumatoid synovial 
      fibroblasts (RSF) in vitro. This was associated with a staurosporine-resistant 
      increase in p55 soluble TNFR levels, in culture media, suggesting that 
      down-modulation was due to enhanced receptor shedding via a protein kinase 
      C-independent mechanism. Pretreatment with rhIL-4 reduced the subsequent tumour 
      necrosis factor alpha (TNF alpha) stimulation of prostaglandin E (PGE) and matrix 
      metalloproteinase-3 (MMP-3) production by RSF. Thus, the potential anti-synovial 
      monokine properties of rhIL-4 are not confined to inhibiting monokine production 
      but also include the ability to interfere with their action on cells that 
      constitute a substantial proportion of the rheumatoid synovium.
FAU - Taylor, D J
AU  - Taylor DJ
AD  - University Department of Medicine, University Hospital of South Manchester, West 
      Didsbury, UK.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Rheumatol Int
JT  - Rheumatology international
JID - 8206885
RN  - 0 (Alkaloids)
RN  - 0 (Antigens, CD)
RN  - 0 (Monokines)
RN  - 0 (Receptors, Tumor Necrosis Factor)
RN  - 0 (Receptors, Tumor Necrosis Factor, Type I)
RN  - 0 (Recombinant Proteins)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 207137-56-2 (Interleukin-4)
RN  - EC 2.7.11.13 (Protein Kinase C)
RN  - H88EPA0A3N (Staurosporine)
SB  - IM
MH  - Alkaloids/pharmacology
MH  - *Antigens, CD
MH  - Arthritis, Rheumatoid/*immunology
MH  - Binding, Competitive/drug effects
MH  - Cells, Cultured
MH  - Down-Regulation/drug effects
MH  - Fibroblasts/immunology
MH  - Humans
MH  - Interleukin-4/immunology/*pharmacology
MH  - Monokines/biosynthesis/drug effects
MH  - Protein Kinase C/antagonists & inhibitors
MH  - Receptors, Tumor Necrosis Factor/*drug effects
MH  - Receptors, Tumor Necrosis Factor, Type I
MH  - Recombinant Proteins/pharmacology
MH  - Staurosporine
MH  - Synovial Membrane/*immunology
MH  - Tumor Necrosis Factor-alpha/biosynthesis/*drug effects
EDAT- 1994/01/01 00:00
MHDA- 1994/01/01 00:01
CRDT- 1994/01/01 00:00
PHST- 1994/01/01 00:00 [pubmed]
PHST- 1994/01/01 00:01 [medline]
PHST- 1994/01/01 00:00 [entrez]
AID - 10.1007/BF00302667 [doi]
PST - ppublish
SO  - Rheumatol Int. 1994;14(1):21-5. doi: 10.1007/BF00302667.