PMID- 7940663
OWN - NLM
STAT- MEDLINE
DCOM- 19941101
LR  - 20190727
IS  - 0041-1132 (Print)
IS  - 0041-1132 (Linking)
VI  - 34
IP  - 10
DP  - 1994 Oct
TI  - Characteristics of white cell-reduced red cells stored in 
      tri-(2-ethylhexyl)trimellitate plastic.
PG  - 895-8
AB  - BACKGROUND: Standard blood storage containers contain extractable plasticizers 
      that accumulate in blood during storage and are an unintended transfusion 
      product. However, extractable plasticizers have a protective effect on the red 
      cell membrane and improve red cell storage variables. Prestorage white cell 
      reduction also improves selected red cell storage variables. STUDY DESIGN AND 
      METHODS: The study evaluated whether the beneficial effect of prestorage white 
      cell reduction would offset the negative effect of the absence of extractable 
      plasticizer in red cells stored in AS-3 for 42 days at 4 degrees C. Filtered red 
      cells stored in polyvinylchloride containers with the nonextracting plasticizer, 
      tri-(2-ethylhexyl)trimellitate (TEHTM), were compared to unfiltered red cells 
      stored in polyvinylchloride containers with the extractable plasticizer 
      di-(2-ethylhexyl)phthalate (DEHP). RESULTS: Poststorage supernatant potassium and 
      red cell osmotic fragility were significantly higher in white cell-reduced TEHTM 
      units than in unfiltered DEHP units. The mean 24-hour recovery of the filtered 
      TEHTM red cells was significantly lower than that of the unfiltered DEHP red 
      cells (69.1 +/- 7.4% vs. 77.1 +/- 5.1%, p < 0.05, n = 8). CONCLUSION: These data 
      demonstrate that white cell reduction before 42-day storage in TEHTM containers 
      with currently approved preservatives does not yield an acceptable red cell 
      component.
FAU - Davey, R J
AU  - Davey RJ
AD  - Department of Transfusion Medicine, National Institutes of Health, Bethesda, 
      Maryland.
FAU - Heaton, W A
AU  - Heaton WA
FAU - Sweat, L T
AU  - Sweat LT
FAU - Stec, N M
AU  - Stec NM
FAU - Nelson, E J
AU  - Nelson EJ
FAU - Holme, S
AU  - Holme S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Transfusion
JT  - Transfusion
JID - 0417360
RN  - 0 (Benzoates)
RN  - 0 (Plasticizers)
RN  - 3319-31-1 (tri-(2-ethylhexyl)trimellitate)
RN  - 8L70Q75FXE (Adenosine Triphosphate)
RN  - RWP5GA015D (Potassium)
SB  - IM
MH  - Adenosine Triphosphate/blood
MH  - *Benzoates
MH  - *Blood Preservation
MH  - Blood Transfusion
MH  - *Erythrocytes
MH  - Filtration/instrumentation
MH  - Hemolysis
MH  - Humans
MH  - *Leukapheresis
MH  - Osmotic Fragility
MH  - Plasticizers
MH  - Potassium/blood
MH  - Time Factors
EDAT- 1994/10/01 00:00
MHDA- 1994/10/01 00:01
CRDT- 1994/10/01 00:00
PHST- 1994/10/01 00:00 [pubmed]
PHST- 1994/10/01 00:01 [medline]
PHST- 1994/10/01 00:00 [entrez]
AID - 10.1046/j.1537-2995.1994.341095026977.x [doi]
PST - ppublish
SO  - Transfusion. 1994 Oct;34(10):895-8. doi: 10.1046/j.1537-2995.1994.341095026977.x.