PMID- 7941779
OWN - NLM
STAT- MEDLINE
DCOM- 19941110
LR  - 20131121
IS  - 1340-2544 (Print)
IS  - 1340-2544 (Linking)
VI  - 14
IP  - 3
DP  - 1994 Jun
TI  - Antitussive effect of (+/-) pentazocine in diabetic mice is mediated by 
      delta-sites, but not by mu- or kappa-opioid receptors.
PG  - 147-52
AB  - The effects of streptozotocin-induced diabetes on the antitussive effect of (+/-) 
      pentazocine were examined in mice. Intracerebroventricular (i.c.v.) 
      administration of (+/-) pentazocine produced a dose-dependent antitussive effect 
      in both diabetic and non-diabetic mice. There were no significant differences in 
      the antitussive effect of (+/-) pentazocine in diabetic and non-diabetic mice. 
      The antitussive effect of i.c.v. (+/-) pentazocine was partially, but 
      significantly, reduced in non-diabetic mice following pretreatment with either 
      beta-funaltrexamine, a selective mu-opioid antagonist, or rimcazole, a specific 
      sigma-site antagonist. The antitussive effect of (+/-) pentazocine in diabetic 
      mice was significantly antagonized by pretreatment with rimcazole. However, 
      beta-funaltrexamine had no effect on the antitussive effect of (+/-) pentazocine 
      in diabetic mice. Furthermore, nor-binaltorphimine, a selective kappa-opioid 
      receptor antagonist, had no significant effect on the antitussive effect of (+/-) 
      pentazocine in either non-diabetic or diabetic mice. These results suggest that 
      although the antitussive effect of i.c.v. (+/-) pentazocine in non-diabetic mice 
      is mediated by both mu-opioid receptors and sigma-sites, in diabetic mice this 
      effect is mainly mediated by sigma-sites.
FAU - Kamei, J
AU  - Kamei J
AD  - Department of Pharmacology, Faculty of Pharmaceutical Sciences, Hoshi University, 
      Tokyo, Japan.
FAU - Iwamoto, Y
AU  - Iwamoto Y
FAU - Misawa, M
AU  - Misawa M
FAU - Nagase, H
AU  - Nagase H
FAU - Kasuya, Y
AU  - Kasuya Y
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Nihon Shinkei Seishin Yakurigaku Zasshi
JT  - Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology
JID - 9509023
RN  - 0 (Antitussive Agents)
RN  - 0 (Receptors, Opioid, delta)
RN  - 0 (Receptors, Opioid, kappa)
RN  - 0 (Receptors, Opioid, mu)
RN  - 5W494URQ81 (Streptozocin)
RN  - RP4A60D26L (Pentazocine)
SB  - IM
MH  - Animals
MH  - Antitussive Agents/administration & dosage/*pharmacology
MH  - *Diabetes Mellitus, Experimental
MH  - Injections, Intraventricular
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Pentazocine/administration & dosage/*pharmacology
MH  - Receptors, Opioid, delta/*agonists
MH  - Receptors, Opioid, kappa
MH  - Receptors, Opioid, mu
MH  - Streptozocin
EDAT- 1994/06/01 00:00
MHDA- 1994/06/01 00:01
CRDT- 1994/06/01 00:00
PHST- 1994/06/01 00:00 [pubmed]
PHST- 1994/06/01 00:01 [medline]
PHST- 1994/06/01 00:00 [entrez]
PST - ppublish
SO  - Nihon Shinkei Seishin Yakurigaku Zasshi. 1994 Jun;14(3):147-52.