PMID- 7942344
OWN - NLM
STAT- MEDLINE
DCOM- 19941122
LR  - 20151008
IS  - 0029-0203 (Print)
IS  - 0029-0203 (Linking)
VI  - 98
IP  - 8
DP  - 1994 Aug
TI  - [Relation between the clinical course of Vogt-Koyanagi-Harada's disease and human 
      leukocyte antigen (HLA)-DR4 subtypes].
PG  - 797-800
AB  - Vogt-Koyanagi-Harada's disease (VKH) is an autoimmune disorder affecting 
      melanocyte-containing tissues. VKH is strongly related to human leukocyte antigen 
      (HLA)-DR4, a heterogeneous HLA specificity consisting of at least 12 different 
      genotypes. The disease has two types: prolonged and non-prolonged, depending upon 
      the clinical course. Fifty-four Japanese patients comprising 27 with the 
      prolonged type, 15 with the non-prolonged type, and 12 new cases of VKH were 
      included in this study. Ninety-three percent of the patients with all types had 
      HLA-DR4. All 27 patients with the prolonged type had either the DRB1*0405 or 
      *0410 genotype, and the non-prolonged type included two DR4-negative and four 
      DRB1*0405 and *0410 negative patients. Our results indicate that the clinical 
      course of VKH is determined partly by the patient's HLA genotype.
FAU - Islam, S M
AU  - Islam SM
AD  - Department of Ophthalmology, University of Tokyo, Faculty of Medicine, Japan.
FAU - Numaga, J
AU  - Numaga J
FAU - Fujino, Y
AU  - Fujino Y
FAU - Matsuki, K
AU  - Matsuki K
FAU - Maeda, H
AU  - Maeda H
FAU - Masuda, K
AU  - Masuda K
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Nippon Ganka Gakkai Zasshi
JT  - Nippon Ganka Gakkai zasshi
JID - 7505716
RN  - 0 (HLA-DR4 Antigen)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Female
MH  - Genotype
MH  - HLA-DR4 Antigen/*classification/genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Uveomeningoencephalitic Syndrome/classification/*immunology
EDAT- 1994/08/01 00:00
MHDA- 1994/08/01 00:01
CRDT- 1994/08/01 00:00
PHST- 1994/08/01 00:00 [pubmed]
PHST- 1994/08/01 00:01 [medline]
PHST- 1994/08/01 00:00 [entrez]
PST - ppublish
SO  - Nippon Ganka Gakkai Zasshi. 1994 Aug;98(8):797-800.