PMID- 7944507
OWN - NLM
STAT- MEDLINE
DCOM- 19941104
LR  - 20201214
IS  - 0003-987X (Print)
IS  - 0003-987X (Linking)
VI  - 130
IP  - 10
DP  - 1994 Oct
TI  - The autoantibody response to Ro/SSA in cutaneous lupus erythematosus.
PG  - 1262-8
AB  - BACKGROUND AND DESIGN: Seventeen patients with subacute cutaneous lupus 
      erythematosus (SCLE) were compared with 15 patients with discoid lupus 
      erythematosus (DLE) to evaluate the relationship of 60- and 52-kd Ro/SSA 
      autoantibodies to the clinical diagnosis and to evaluate assays for anti-Ro/SSA. 
      RESULTS: All serum samples from patients with SCLE had precipitating anti-Ro/SSA 
      antibodies in immunodiffusion, and all had high titer anti-60-kd Ro/SSA in 
      enzyme-linked immunosorbent assay. Immunoblotting was inadequately sensitive for 
      detecting anti-60-kd Ro/SSA. Fifteen patients with SCLE had anti-52-kd Ro/SSA (11 
      high titer, four low titer). Only one of the 15 patients with DLE had 
      precipitating, high-titer anti-Ro/SSA. Nine other patients with DLE had low-titer 
      anti-60-kd Ro/SSA, and four had low-titer anti-52-kd Ro-SSA. Low-titer 
      anti-Ro/SSA did not confer an increased risk for photosensitivity in the DLE 
      group. CONCLUSIONS: High-titer, precipitating antibodies to Ro/SSA are typical of 
      SCLE and unusual in DLE. Low-titer, nonprecipitating antibodies to Ro/SSA are 
      common in DLE and could be an indication of pathogenic factors shared with SCLE. 
      However, low titers of anti-Ro/SSA do not confer a significant risk for SCLE skin 
      lesions. For the purpose of clinical evaluation of skin disease, immunodiffusion 
      assays for anti-Ro/SSA are cost-effective and informative.
FAU - Lee, L A
AU  - Lee LA
AD  - Department of Dermatology, University of Oklahoma Health Sciences Center, 
      Oklahoma City.
FAU - Roberts, C M
AU  - Roberts CM
FAU - Frank, M B
AU  - Frank MB
FAU - McCubbin, V R
AU  - McCubbin VR
FAU - Reichlin, M
AU  - Reichlin M
LA  - eng
GR  - AI 21568/AI/NIAID NIH HHS/United States
GR  - AR 31133/AR/NIAMS NIH HHS/United States
GR  - AR 32214/AR/NIAMS NIH HHS/United States
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Arch Dermatol
JT  - Archives of dermatology
JID - 0372433
RN  - 0 (Autoantigens)
RN  - 0 (RNA, Small Cytoplasmic)
RN  - 0 (RO60 protein, human)
RN  - 0 (Ribonucleoproteins)
RN  - 0 (SS-A antigen)
SB  - IM
CIN - Arch Dermatol. 1994 Oct;130(10):1308-10. PMID: 7944515
MH  - Autoantigens/blood/*immunology
MH  - Humans
MH  - Lupus Erythematosus, Cutaneous/blood/*immunology
MH  - Lupus Erythematosus, Discoid/immunology
MH  - *RNA, Small Cytoplasmic
MH  - Ribonucleoproteins/blood/*immunology
EDAT- 1994/10/01 00:00
MHDA- 1994/10/01 00:01
CRDT- 1994/10/01 00:00
PHST- 1994/10/01 00:00 [pubmed]
PHST- 1994/10/01 00:01 [medline]
PHST- 1994/10/01 00:00 [entrez]
PST - ppublish
SO  - Arch Dermatol. 1994 Oct;130(10):1262-8.