PMID- 7949085
OWN - NLM
STAT- MEDLINE
DCOM- 19941220
LR  - 20210216
IS  - 0006-4971 (Print)
IS  - 0006-4971 (Linking)
VI  - 84
IP  - 10
DP  - 1994 Nov 15
TI  - Human herpesvirus 6 (HHV-6) isolation from bone marrow: HHV-6-associated bone 
      marrow suppression in bone marrow transplant patients.
PG  - 3307-10
AB  - These studies tested the hypothesis that human herpesvirus 6 (HHV-6) can cause 
      posttransplant bone marrow (BM) suppression in BM transplant (BMT) patients. 
      Fifteen adult patients who received T-lymphocyte-depleted, allogeneic BM 
      transplants and who developed posttransplant BM suppression were studied. 
      Detailed chart reviews were used to divide the patients into two groups: (1) 
      those with diagnosed BM suppression (DBMS) and (2) those with idiopathic BM 
      suppression (IBMS). BM aspirates obtained from the patients at the onset of BM 
      suppression were subjected to an HHV-6 isolation procedure using 
      mitogen-stimulated blood mononuclear cells. BM specimens obtained from another 
      population of BMT patients solely to document engraftment irrespective of their 
      BM function were also subjected to the HHV-6 isolation procedure as controls. 
      HHV-6 was isolated from 6 of 15 BM samples from BMT patients with BM suppression. 
      BM samples from patients with IBMS were more likely to be positive for HHV-6 than 
      those from patients with DBMS (P < .01). Also, HHV-6-positive BM were 
      significantly more likely (P < .05) to come from patients with suppression of 
      more than one BM lineage than HHV-6-negative BM. Finally, samples of BM from an 
      unselected series of BMT patients studied without regard to their BM function 
      were less likely (P < .01) to be positive for HHV-6 than patients with IBMS.
FAU - Carrigan, D R
AU  - Carrigan DR
AD  - Department of Pathology, Medical College of Wisconsin, Milwaukee 53226.
FAU - Knox, K K
AU  - Knox KK
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
SB  - IM
CIN - Blood. 1995 Jul 15;86(2):835-6. PMID: 7606018
MH  - Adult
MH  - Biopsy, Needle
MH  - Bone Marrow/pathology/*virology
MH  - Bone Marrow Transplantation/*pathology
MH  - Female
MH  - Follow-Up Studies
MH  - Herpesvirus 6, Human/*isolation & purification
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Time Factors
MH  - Transplantation, Homologous
EDAT- 1994/11/15 00:00
MHDA- 1994/11/15 00:01
CRDT- 1994/11/15 00:00
PHST- 1994/11/15 00:00 [pubmed]
PHST- 1994/11/15 00:01 [medline]
PHST- 1994/11/15 00:00 [entrez]
AID - S0006-4971(20)73907-8 [pii]
PST - ppublish
SO  - Blood. 1994 Nov 15;84(10):3307-10.