PMID- 79524
OWN - NLM
STAT- MEDLINE
DCOM- 19781027
LR  - 20041117
IS  - 0323-4347 (Print)
IS  - 0323-4347 (Linking)
VI  - 105
IP  - 2
DP  - 1978
TI  - Deficiency of beta-glucuronidase in neutrophils from patients with precancerous 
      states of the larynx.
PG  - 194-9
AB  - Activity of beta-glucuronidase (GR) and acid phosphatase (AP) has been determined 
      in peripheral blood neutrophils from 24 men with precancerous states of the 
      larynx that is leukoplakia papillomas and pachydermia by means cytochemical 
      methods described by Hayashi et al., and Barka and Anderson, respectively. The 
      results obtained were expressed in terms of absolute counts of enzyme-positive 
      and enzyme-negative cells with regard to enzyme activity variation within the 
      enzyme-positive neutrophil population; the enzyme activity index score has been 
      calculated. The control group consisted of 20 healthy subjects of the same sex. 
      No significant alterations were found so far as AP activity is concerned between 
      the group studied. In contrast, activity of GR in patients with precancerous 
      states exhibited significant lowering. The most striking feature was in almost 
      complete absence from the blood of GR-positive neutrophils with high activity of 
      the enzyme. Majority of these cells showed only traces of the GR activity. 
      According to authors opinion the deficiency of GR in neutrophils of patients with 
      precancerous lesions pertains to problem of neutrophil-mediated cytotoxic effect 
      against mammalian tumour cells.
FAU - Lisiewicz, J
AU  - Lisiewicz J
FAU - Gierek, T
AU  - Gierek T
FAU - Pilch, J
AU  - Pilch J
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Folia Haematol Int Mag Klin Morphol Blutforsch
JT  - Folia haematologica (Leipzig, Germany : 1928)
JID - 0374615
RN  - EC 3.1.3.2 (Acid Phosphatase)
RN  - EC 3.2.1.31 (Glucuronidase)
SB  - IM
MH  - Acid Phosphatase/metabolism
MH  - Adult
MH  - Glucuronidase/*deficiency/metabolism
MH  - Humans
MH  - *Laryngeal Neoplasms
MH  - Male
MH  - Middle Aged
MH  - Neutrophils/*enzymology
MH  - Precancerous Conditions/*enzymology
EDAT- 1978/01/01 00:00
MHDA- 1978/01/01 00:01
CRDT- 1978/01/01 00:00
PHST- 1978/01/01 00:00 [pubmed]
PHST- 1978/01/01 00:01 [medline]
PHST- 1978/01/01 00:00 [entrez]
PST - ppublish
SO  - Folia Haematol Int Mag Klin Morphol Blutforsch. 1978;105(2):194-9.