PMID- 795301
OWN - NLM
STAT- MEDLINE
DCOM- 19770224
LR  - 20190626
IS  - 0002-9343 (Print)
IS  - 0002-9343 (Linking)
VI  - 61
IP  - 6
DP  - 1976 Dec
TI  - Monoclonal IgE with renal failure.
PG  - 957-62
AB  - Only four cases of immunoglobulin E (IgE) monoclonal "gammapathies" have been 
      reported previously. Discussed here is a 57 year old man who presented with 
      hypertension and the nephrotic syndrome. A monoclonal IgE-kappa component (0.6 
      mg/ml), which did not appear as an M spike on protein electrophoresis, was 
      demonstrated by immunoelectrophoresis in the serum and urine. The patient's 
      condition deteriorated rapidly due to renal failure, and he died five weeks after 
      the diagnosis was made. Pathologic examination disclosed extensive glomerular 
      lesions, but amyloid was not detected by light or electron microscopy. The 
      possible relationship between the monoclonal gammapathy and kidney impairment is 
      discussed.
FAU - Vladutiu, A O
AU  - Vladutiu AO
FAU - Kohli, R K
AU  - Kohli RK
FAU - Prezyna, A P
AU  - Prezyna AP
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Am J Med
JT  - The American journal of medicine
JID - 0267200
RN  - 37341-29-0 (Immunoglobulin E)
RN  - Q41OR9510P (Melphalan)
RN  - VB0R961HZT (Prednisone)
SB  - IM
MH  - Acute Kidney Injury/*complications/drug therapy/pathology
MH  - Fluorescent Antibody Technique
MH  - Humans
MH  - Hypergammaglobulinemia/*complications
MH  - Hypertension/*complications
MH  - Immunoglobulin E/*analysis
MH  - Kidney/pathology
MH  - Male
MH  - Melphalan/therapeutic use
MH  - Middle Aged
MH  - Prednisone/therapeutic use
EDAT- 1976/12/01 00:00
MHDA- 1976/12/01 00:01
CRDT- 1976/12/01 00:00
PHST- 1976/12/01 00:00 [pubmed]
PHST- 1976/12/01 00:01 [medline]
PHST- 1976/12/01 00:00 [entrez]
AID - 0002-9343(76)90422-8 [pii]
AID - 10.1016/0002-9343(76)90422-8 [doi]
PST - ppublish
SO  - Am J Med. 1976 Dec;61(6):957-62. doi: 10.1016/0002-9343(76)90422-8.