PMID- 7953731
OWN - NLM
STAT- MEDLINE
DCOM- 19941229
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 652
IP  - 2
DP  - 1994 Aug 1
TI  - Elevation of plasma ACTH concentration in rabbits made febrile by systemic 
      injection of bacterial endotoxin.
PG  - 201-6
AB  - This study was carried out to investigate the adrenocorticotropic hormone (ACTH) 
      response in rabbits made febrile by systemic injection of lipopolysaccharide 
      (LPS, Salmonella typhosa endotoxin). Intravenous (i.v.) injection of LPS (0.1 
      microgram/kg and 1.0 microgram/kg) increased rectal temperature (biphasic fever) 
      and the plasma concentration of ACTH (ACTH response) in a dose-related manner. 
      These responses were suppressed by pretreatment with indomethacin (20 mg/kg, 
      subcutaneously). Intracerebroventricular (i.c.v.) administration of indomethacin 
      (400 micrograms) had no effect on the ACTH response to LPS, although it 
      significantly suppressed febrile response. Small increases in plasma 
      concentration of ACTH and significant fevers followed i.c.v. administration of 
      prostaglandin E2 (2 micrograms) or F2 alpha (2 micrograms). I.v. administration 
      of corticotropin releasing factor (CRF) antagonist [alpha-helical CRF (9-41) (200 
      micrograms/kg)] partly suppressed the ACTH increase induced in plasma by i.v. 
      LPS. These results suggest that prostaglandins synthesized outside the 
      blood-brain barrier play an important role in the ACTH response and that the 
      mechanism for induction of the ACTH response is not exactly the same as that for 
      the febrile response, although prostaglandins are involved in both responses.
FAU - Watanabe, T
AU  - Watanabe T
AD  - Department of Physiology, Yamaguchi University School of Medicine, Japan.
FAU - Clark, W G
AU  - Clark WG
FAU - Ceriani, G
AU  - Ceriani G
FAU - Lipton, J M
AU  - Lipton JM
LA  - eng
GR  - NS10046/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Lipopolysaccharides)
RN  - 0 (alpha helical corticotropin-releasing hormone)
RN  - 9002-60-2 (Adrenocorticotropic Hormone)
RN  - 9015-71-8 (Corticotropin-Releasing Hormone)
RN  - K7Q1JQR04M (Dinoprostone)
RN  - XXE1CET956 (Indomethacin)
SB  - IM
MH  - Adrenocorticotropic Hormone/*blood
MH  - Animals
MH  - Body Temperature/drug effects
MH  - Corticotropin-Releasing Hormone/antagonists & inhibitors/pharmacology
MH  - Dinoprostone/administration & dosage/pharmacology
MH  - Fever/*blood/chemically induced
MH  - Indomethacin/administration & dosage/pharmacology
MH  - Injections, Intravenous
MH  - Injections, Intraventricular
MH  - Lipopolysaccharides/administration & dosage/*pharmacology
MH  - Male
MH  - Rabbits
MH  - Salmonella typhi/metabolism
EDAT- 1994/08/01 00:00
MHDA- 1994/08/01 00:01
CRDT- 1994/08/01 00:00
PHST- 1994/08/01 00:00 [pubmed]
PHST- 1994/08/01 00:01 [medline]
PHST- 1994/08/01 00:00 [entrez]
AID - 0006-8993(94)90228-3 [pii]
AID - 10.1016/0006-8993(94)90228-3 [doi]
PST - ppublish
SO  - Brain Res. 1994 Aug 1;652(2):201-6. doi: 10.1016/0006-8993(94)90228-3.