PMID- 7954741
OWN - NLM
STAT- MEDLINE
DCOM- 19941208
LR  - 20170214
IS  - 0333-1024 (Print)
IS  - 0333-1024 (Linking)
VI  - 14
IP  - 3
DP  - 1994 Jun
TI  - Platelet 3H-imipramine binding and sulphotransferase activity in primary 
      headache.
PG  - 210-4
AB  - We investigated platelet 3H-imipramine (3H-IMI) binding, a putative peripheral 
      serotonergic marker, and the activity of sulphotransferase (ST), an enzyme 
      involved in the catabolism of catecholamines and phenolic compounds, in 14 
      patients suffering from migraine without aura (MWoA) and in 10 with tension-type 
      headache (TH), as compared with a group of controls. The possible relationships 
      between the biological parameters and clinical features were also examined. The 
      results showed that the two groups of patients had a lower number of 3H-IMI 
      binding sites and a lower activity of the thermolabile form of ST, which acts 
      preferentially on monoamine substrates, than the healthy controls, with no 
      intergroup differences. Significant correlations between psychopathological 
      rating scales and characteristics of the illness were observed in the patients 
      with TH. The decreased number of platelet 3H-IMI binding sites is suggestive of a 
      presynaptic serotonergic dysfunction and confirms the involvement of 5HT in 
      primary headaches. The reduced ST activity might produce changes in the level of 
      sulphated biogenic amines, including dopamine and tyramine, which might have an 
      additional role in the pathophysiology of some aspects of primary headache.
FAU - Marazziti, D
AU  - Marazziti D
AD  - Institute of Psychiatry, University of Pisa, Italy.
FAU - Bonuccelli, U
AU  - Bonuccelli U
FAU - Nuti, A
AU  - Nuti A
FAU - Toni, C
AU  - Toni C
FAU - Pedri, S
AU  - Pedri S
FAU - Palego, L
AU  - Palego L
FAU - Pavese, N
AU  - Pavese N
FAU - Lucetti, C
AU  - Lucetti C
FAU - Muratorio, A
AU  - Muratorio A
FAU - Cassano, G B
AU  - Cassano GB
LA  - eng
PT  - Journal Article
PL  - England
TA  - Cephalalgia
JT  - Cephalalgia : an international journal of headache
JID - 8200710
RN  - 0 (Carrier Proteins)
RN  - 0 (Receptors, Drug)
RN  - 0 (imipramine receptor)
RN  - 333DO1RDJY (Serotonin)
RN  - EC 2.8.2.1 (Arylsulfotransferase)
RN  - OGG85SX4E4 (Imipramine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Arylsulfotransferase/*blood
MH  - Blood Platelets/*enzymology
MH  - Carrier Proteins/*metabolism
MH  - Female
MH  - Headache/*enzymology
MH  - Humans
MH  - Imipramine/*pharmacokinetics
MH  - Male
MH  - Middle Aged
MH  - Migraine Disorders/*enzymology
MH  - Receptors, Drug/*metabolism
MH  - Reference Values
MH  - Serotonin/physiology
EDAT- 1994/06/01 00:00
MHDA- 1994/06/01 00:01
CRDT- 1994/06/01 00:00
PHST- 1994/06/01 00:00 [pubmed]
PHST- 1994/06/01 00:01 [medline]
PHST- 1994/06/01 00:00 [entrez]
AID - 10.1046/j.1468-2982.1994.014003210.x [doi]
PST - ppublish
SO  - Cephalalgia. 1994 Jun;14(3):210-4. doi: 10.1046/j.1468-2982.1994.014003210.x.