PMID- 7954742
OWN - NLM
STAT- MEDLINE
DCOM- 19941208
LR  - 20170214
IS  - 0333-1024 (Print)
IS  - 0333-1024 (Linking)
VI  - 14
IP  - 3
DP  - 1994 Jun
TI  - Platelet superoxide dismutase in migraine and tension-type headache.
PG  - 215-8; discussion 181
AB  - Superoxide dismutase (SOD) is a radical-scavenging enzyme. We determined Cu, 
      Zn-SOD concentrations and activities in platelets from subjects with migraine and 
      tension-type headaches. Thirty migraine without aura (MWoA) patients, 9 migraine 
      with aura (MWA) patients, and 53 tension-type headache patients were selected for 
      study. Thirty healthy volunteers composed the control group. Concentrations of 
      platelet SOD were determined using enzyme-linked immunosorbent assay techniques. 
      The activity of platelet SOD was determined by measuring reductivity of nitroblue 
      tetrazolium. Low concentrations of platelet SOD were found in patients with MWA 
      and MWoA. Platelet SOD activity decreased in MWA patients but not in patients 
      with MWoA or tension-type headaches. These findings suggest vulnerability to 
      oxidative stress in patients with migraine. It is suggested that low platelet SOD 
      levels may play an important role in the etiology of migraine.
FAU - Shimomura, T
AU  - Shimomura T
AD  - Division of Neurology, Faculty of Medicine, Tottori University, Yonago, Japan.
FAU - Kowa, H
AU  - Kowa H
FAU - Nakano, T
AU  - Nakano T
FAU - Kitano, A
AU  - Kitano A
FAU - Marukawa, H
AU  - Marukawa H
FAU - Urakami, K
AU  - Urakami K
FAU - Takahashi, K
AU  - Takahashi K
LA  - eng
PT  - Journal Article
PL  - England
TA  - Cephalalgia
JT  - Cephalalgia : an international journal of headache
JID - 8200710
RN  - 0 (Free Radicals)
RN  - 0 (Reactive Oxygen Species)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
SB  - IM
MH  - Adult
MH  - Blood Platelets/*enzymology
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Free Radicals
MH  - Headache/*enzymology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Migraine Disorders/*enzymology
MH  - Oxidative Stress
MH  - Reactive Oxygen Species/metabolism
MH  - Reference Values
MH  - Superoxide Dismutase/*blood
EDAT- 1994/06/01 00:00
MHDA- 1994/06/01 00:01
CRDT- 1994/06/01 00:00
PHST- 1994/06/01 00:00 [pubmed]
PHST- 1994/06/01 00:01 [medline]
PHST- 1994/06/01 00:00 [entrez]
AID - 10.1046/j.1468-2982.1994.014003215.x [doi]
PST - ppublish
SO  - Cephalalgia. 1994 Jun;14(3):215-8; discussion 181. doi: 
      10.1046/j.1468-2982.1994.014003215.x.