PMID- 7955113
OWN - NLM
STAT- MEDLINE
DCOM- 19941222
LR  - 20190512
IS  - 0143-3334 (Print)
IS  - 0143-3334 (Linking)
VI  - 15
IP  - 11
DP  - 1994 Nov
TI  - Substance-dependent sex differences in the activation of benzylic alcohols to 
      mutagens by hepatic sulfotransferases of the rat.
PG  - 2605-11
AB  - Six primary and 10 secondary benzylic alcohols derived from polycyclic aromatic 
      hydrocarbons were tested for mutagenicity in Salmonella typhimurium TA98 in the 
      presence of varying amounts of hepatic cytosol from adult male and female rats 
      and 3'-phosphoadenosine-5'-phosphosulfate, the cofactor for sulfotransferases. 
      With the exception of 1-(9-anthryl)ethanol, 4H-cyclopenta[def]-phenanthren-4-ol 
      and 10-hydroxy-7,8,9,10-tetrahydrobenzo[a]pyrene, all the benzylic alcohols were 
      activated to mutagens. For 1-(1-pyrenyl)ethanol (1-HEP), 1-(2-pyrenyl)ethanol 
      (2-HEP), 6-hydroxymethylanthanthrene (6-HMAA), 2-hydroxymethylpyrene (2-HMP), 
      10H-indeno[1,2,7,7a-bcd]pyren-10-ol (OH-IP), 
      3-hydroxy-3,4-dihydrocyclopenta[cd]pyrene (3-OH-H2-CPcdP) and 
      1-(6-benzo[a]pyrenyl)ethanol (6-HEBP), this is the first observation of a 
      mutagenic activity. The primary alcohols 1-hydroxymethylpyrene, 2-HMP, 
      9-hydroxymethylanthracene, 7-hydroxymethyl-12-methylbenz[a]anthracene and 
      6-hydroxymethylbenzo[a]pyrene, as well as the secondary alcohols 1-HEP and 
      3-OH-H2-CPcdP, were more efficiently activated by hepatic cytosol from females 
      than by preparations from males (2.6- to 8-fold). A further compound, 6-HEBP 
      showed significant, but relatively weak, effects in the presence of cytosol from 
      females, whereas it was inactive in the presence of hepatic cytosol from males. 
      The reverse sex difference was observed in the activation of 
      4H-cyclo-penta[def]chrysen-4-ol, the activity of cytosol from males amounting to 
      about four times that from females. Four other compounds, 2-HEP, 
      7-hydroxy-7,8,9,10-tetrahydrobenzo[a]pyrene, 6-HMAA and OH-IP, were activated 
      with similar efficiency by hepatic cytosol from both sexes (< two-fold 
      differences). The study indicates that different sulfotransferases are involved 
      in the bioactivation of benzylic alcohols, including forms preferentially 
      expressed in females as well as forms preferentially expressed in males, and that 
      these enzymes qualitatively differ in their substrate tolerance for benzylic 
      alcohols.
FAU - Glatt, H
AU  - Glatt H
AD  - Deutsches Institut fur Ernahrungsforschung, Potsdam-Rehbrucke, Germany.
FAU - Pauly, K
AU  - Pauly K
FAU - Frank, H
AU  - Frank H
FAU - Seidel, A
AU  - Seidel A
FAU - Oesch, F
AU  - Oesch F
FAU - Harvey, R G
AU  - Harvey RG
FAU - Werle-Schneider, G
AU  - Werle-Schneider G
LA  - eng
GR  - ES 04266/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Carcinogenesis
JT  - Carcinogenesis
JID - 8008055
RN  - 0 (Benzyl Alcohols)
RN  - 0 (Mutagens)
RN  - EC 2.8.2.- (Sulfotransferases)
SB  - IM
MH  - Animals
MH  - Benzyl Alcohols/*metabolism
MH  - Biotransformation
MH  - Female
MH  - Liver/*enzymology
MH  - Male
MH  - Mutagens/*metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Sex Factors
MH  - Sulfotransferases/*physiology
EDAT- 1994/11/01 00:00
MHDA- 1994/11/01 00:01
CRDT- 1994/11/01 00:00
PHST- 1994/11/01 00:00 [pubmed]
PHST- 1994/11/01 00:01 [medline]
PHST- 1994/11/01 00:00 [entrez]
AID - 10.1093/carcin/15.11.2605 [doi]
PST - ppublish
SO  - Carcinogenesis. 1994 Nov;15(11):2605-11. doi: 10.1093/carcin/15.11.2605.