PMID- 7956632
OWN - NLM
STAT- MEDLINE
DCOM- 19941202
LR  - 20190515
IS  - 0149-5992 (Print)
IS  - 0149-5992 (Linking)
VI  - 17
IP  - 8
DP  - 1994 Aug
TI  - HLA-DQB1 codon 57 and IDDM in Chinese living in Taiwan.
PG  - 863-8
AB  - OBJECTIVE: To study the human leukocyte antigen (HLA)-DQB1 genetic background in 
      the Chinese population in Taiwan and its association with the low incidence of 
      insulin-dependent diabetes mellitus (IDDM) in this population. RESEARCH DESIGN 
      AND METHODS: Forty-eight IDDM patients and 59 nondiabetic unrelated control 
      subjects were recruited from the population in Taiwan. HLA-DQB1 exon 2 was 
      enzymatically amplified by polymerase chain reaction. HLA-DQB1 alleles were 
      diagnosed by dot blotting and hybridization with 16 sequence-specific 
      oligonucleotide probes. RESULTS: DQB1*0201 and DQB1*0302 alleles were more 
      frequent and DQB1*0301 and DQB1*0601 were less frequent in Chinese with IDDM than 
      in control subjects. Genotypes for homozygous non-aspartic acid residue (NA/NA) 
      at position 57 were positively associated with IDDM at a relative risk of 4.34 (P 
      < 0.001), and those for homozygous aspartic acid (A/A) were negatively associated 
      with IDDM at a relative risk of 0.14 (P < 0.001). Among the NA/A heterozygotes, 
      only DQB1*0201/DQB1*0303 was significantly increased in IDDM subjects. 
      CONCLUSIONS: The amino acid residue at position 57 of HLA-DQ beta-chain is 
      significantly associated with the development or prevention of IDDM in Chinese 
      subjects living in Taiwan. Other genetic and environmental factors may also play 
      important roles in pathogenesis of IDDM.
FAU - Chuang, L M
AU  - Chuang LM
AD  - Department of Internal Medicine, National Taiwan University, Taipei.
FAU - Jou, T S
AU  - Jou TS
FAU - Hu, C Y
AU  - Hu CY
FAU - Wu, H P
AU  - Wu HP
FAU - Tsai, W Y
AU  - Tsai WY
FAU - Lee, J S
AU  - Lee JS
FAU - Hsieh, R P
AU  - Hsieh RP
FAU - Chen, K H
AU  - Chen KH
FAU - Tai, T Y
AU  - Tai TY
FAU - Lin, B J
AU  - Lin BJ
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Diabetes Care
JT  - Diabetes care
JID - 7805975
RN  - 0 (Codon)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 30KYC7MIAI (Aspartic Acid)
SB  - IM
MH  - Adolescent
MH  - Alleles
MH  - Aspartic Acid
MH  - China/ethnology
MH  - Codon
MH  - Diabetes Mellitus, Type 1/epidemiology/*genetics/*immunology
MH  - Gene Frequency
MH  - Genotype
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DQ beta-Chains
MH  - Homozygote
MH  - Humans
MH  - Incidence
MH  - Reference Values
MH  - Regression Analysis
MH  - Taiwan
EDAT- 1994/08/01 00:00
MHDA- 1994/08/01 00:01
CRDT- 1994/08/01 00:00
PHST- 1994/08/01 00:00 [pubmed]
PHST- 1994/08/01 00:01 [medline]
PHST- 1994/08/01 00:00 [entrez]
AID - 10.2337/diacare.17.8.863 [doi]
PST - ppublish
SO  - Diabetes Care. 1994 Aug;17(8):863-8. doi: 10.2337/diacare.17.8.863.