PMID- 7958500
OWN - NLM
STAT- MEDLINE
DCOM- 19941222
LR  - 20190515
IS  - 0012-1797 (Print)
IS  - 0012-1797 (Linking)
VI  - 43
IP  - 12
DP  - 1994 Dec
TI  - Parental origin of diabetes-associated HLA types in sibling pairs with type I 
      diabetes.
PG  - 1462-8
AB  - Genetic susceptibility to type I diabetes is partly determined by genes located 
      in the human leukocyte antigen (HLA) region on chromosome 6. It has been claimed 
      that the transmission of HLA-encoded susceptibility is influenced by parental 
      sex. Fathers are reported to transmit HLA-DR4 haplotypes more frequently to their 
      diabetic offspring than mothers. More recently, it has been suggested that the 
      presence of HLA-DR4 in a mother may influence susceptibility in her offspring, 
      even when it is not inherited. We have analyzed 172 multiplex diabetic pedigrees 
      from the U.K. and find no evidence to support an important effect of parental sex 
      on the inheritance of HLA-encoded susceptibility. Examination of a further 110 
      pedigrees from the U.S. supports this finding. These results have important 
      implications for strategies involving genetic screening for type I diabetes.
FAU - Bain, S C
AU  - Bain SC
AD  - Department of Medicine, Birmingham Heartlands Hospital, U.K.
FAU - Rowe, B R
AU  - Rowe BR
FAU - Barnett, A H
AU  - Barnett AH
FAU - Todd, J A
AU  - Todd JA
LA  - eng
GR  - Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Diabetes
JT  - Diabetes
JID - 0372763
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DR3 Antigen)
RN  - 0 (HLA-DR4 Antigen)
SB  - IM
MH  - Adolescent
MH  - Child
MH  - *Chromosomes, Human, Pair 6
MH  - Diabetes Mellitus, Type 1/*genetics/immunology
MH  - Fathers
MH  - Female
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DR3 Antigen/genetics
MH  - HLA-DR4 Antigen/genetics
MH  - Haplotypes
MH  - Humans
MH  - Male
MH  - Mothers
MH  - Pedigree
EDAT- 1994/12/01 00:00
MHDA- 1994/12/01 00:01
CRDT- 1994/12/01 00:00
PHST- 1994/12/01 00:00 [pubmed]
PHST- 1994/12/01 00:01 [medline]
PHST- 1994/12/01 00:00 [entrez]
AID - 10.2337/diab.43.12.1462 [doi]
PST - ppublish
SO  - Diabetes. 1994 Dec;43(12):1462-8. doi: 10.2337/diab.43.12.1462.