PMID- 7958733
OWN - NLM
STAT- MEDLINE
DCOM- 19941208
LR  - 20190825
IS  - 0306-3623 (Print)
IS  - 0306-3623 (Linking)
VI  - 25
IP  - 4
DP  - 1994 Jul
TI  - Lack of involvement of delta-opioid receptor in mediating physical dependence at 
      the hypothalamus-pituitary-adrenocortical (HPA) axis in the rat.
PG  - 719-23
AB  - 1. In previous studies, we have demonstrated that delta-opioid receptors are 
      involved both in the acute control of hypothalamus-pituitary-adrenocortical (HPA) 
      axis activity and in the development of neuroendocrine opioid tolerance. In the 
      present work we studied whether central delta-opioid receptors play a role in the 
      development of neuroendocrine physical dependence to opioids in the rat. 2. 
      Intracerebroventricular (i.c.v.) administration of the delta-selective agonist 
      DPDPE ([D-Pen2,D-Pen2]enkephalin) produced stimulation of HPA activity, as shown 
      by an increase in corticosterone release. This effect was antagonized by i.c.v. 
      co-administration of ICI 174,864, a selective delta-receptor antagonist, which 
      provide direct evidence that the activation of the HPA axis produced by DPDPE is 
      mediated by central delta-opioid receptor. 3. Chronic pretreatment with i.c.v. 
      DPDPE resulted in tolerance to its neuroendocrine effect. Intracerebroventricular 
      injection of ICI 174,864 to DPDPE-tolerant rats produced neither alteration in 
      corticosterone release nor behaviour signs of dependence. 4. It was concluded 
      that delta-opioid receptors do not play a role in the development of opioid 
      neuroendocrine physical dependence at the HPA axis.
FAU - Gonzalvez, M L
AU  - Gonzalvez ML
AD  - Department of Physiology and Pharmacology, University School of Medicine, Murcia, 
      Spain.
FAU - Vargas, M L
AU  - Vargas ML
FAU - Milanes, M V
AU  - Milanes MV
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Gen Pharmacol
JT  - General pharmacology
JID - 7602417
RN  - 0 (Enkephalins)
RN  - 0 (Receptors, Opioid, delta)
RN  - 58822-25-6 (Enkephalin, Leucine)
RN  - 88373-73-3 (Enkephalin, D-Penicillamine (2,5)-)
RN  - 89352-67-0 (N,N-diallyl-tyrosyl-alpha-aminoisobutyric acid-phenylalanyl-leucine)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Animals
MH  - Corticosterone/blood
MH  - Enkephalin, D-Penicillamine (2,5)-
MH  - Enkephalin, Leucine/analogs & derivatives/pharmacology
MH  - Enkephalins/pharmacology
MH  - Hypothalamo-Hypophyseal System/*drug effects/physiology
MH  - Male
MH  - Opioid-Related Disorders/*etiology
MH  - Pituitary-Adrenal System/*drug effects/physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, Opioid, delta/*physiology
EDAT- 1994/07/01 00:00
MHDA- 1994/07/01 00:01
CRDT- 1994/07/01 00:00
PHST- 1994/07/01 00:00 [pubmed]
PHST- 1994/07/01 00:01 [medline]
PHST- 1994/07/01 00:00 [entrez]
AID - 0306-3623(94)90251-8 [pii]
AID - 10.1016/0306-3623(94)90251-8 [doi]
PST - ppublish
SO  - Gen Pharmacol. 1994 Jul;25(4):719-23. doi: 10.1016/0306-3623(94)90251-8.