PMID- 7959462
OWN - NLM
STAT- MEDLINE
DCOM- 19941223
LR  - 20190830
IS  - 0278-6915 (Print)
IS  - 0278-6915 (Linking)
VI  - 32
IP  - 11
DP  - 1994 Nov
TI  - Assessment of contact sensitivity of four thiourea rubber accelerators: 
      comparison of two mouse lymph node assays with the guinea pig maximization test.
PG  - 1067-72
AB  - Contact sensitivity of four thiourea rubber accelerators, diphenylthiourea 
      (DPTU), dilaurylthiourea (DLTU), dibutylthiourea (DBTU) and diethylthiourea 
      (DETU), was evaluated by a new sensitive mouse lymph node assay (SLNA) and the 
      murine local lymph node assay (LLNA). The results of the SLNA and LLNA were 
      compared with the data of the guinea pig maximization test (GPMT). In the LLNA 
      and SLNA, the sensitizing activity was measured as a function of draining lymph 
      node activation following application of the test chemicals. Of these four 
      thioureas, three (DETU, DBTU and DPTU) were not classified as skin sensitizers in 
      the LLNA. The SLNA successfully detected the sensitivity of all thioureas tested. 
      This result indicated that the SLNA was, in these cases, more sensitive than the 
      LLNA for identification of contact allergens. The order of sensitization 
      potential observed from the SLNA was DPTU (greatest), DLTU, DBTU and then DETU 
      (least). The predictions of sensitizing potential and the order of the 
      sensitizing capacity of four thioureas by the SLNA and the GPMT are very similar.
FAU - Ikarashi, Y
AU  - Ikarashi Y
AD  - National Institute of Health Sciences, Tokyo, Japan.
FAU - Ohno, K
AU  - Ohno K
FAU - Momma, J
AU  - Momma J
FAU - Tsuchiya, T
AU  - Tsuchiya T
FAU - Nakamura, A
AU  - Nakamura A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Food Chem Toxicol
JT  - Food and chemical toxicology : an international journal published for the British 
      Industrial Biological Research Association
JID - 8207483
RN  - GYV9AM2QAG (Thiourea)
SB  - IM
MH  - Administration, Topical
MH  - Animals
MH  - *Dermatitis, Contact
MH  - Female
MH  - Guinea Pigs
MH  - Injections, Intradermal
MH  - Lymph Nodes/*drug effects
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Species Specificity
MH  - Thiourea/*adverse effects/*analogs & derivatives
EDAT- 1994/11/01 00:00
MHDA- 1994/11/01 00:01
CRDT- 1994/11/01 00:00
PHST- 1994/11/01 00:00 [pubmed]
PHST- 1994/11/01 00:01 [medline]
PHST- 1994/11/01 00:00 [entrez]
AID - 0278-6915(94)90148-1 [pii]
AID - 10.1016/0278-6915(94)90148-1 [doi]
PST - ppublish
SO  - Food Chem Toxicol. 1994 Nov;32(11):1067-72. doi: 10.1016/0278-6915(94)90148-1.