PMID- 7959678
OWN - NLM
STAT- MEDLINE
DCOM- 19941215
LR  - 20221207
IS  - 0340-6717 (Print)
IS  - 0340-6717 (Linking)
VI  - 94
IP  - 5
DP  - 1994 Nov
TI  - Multiple endocrine neoplasia type 1 (MEN1) in two Asian families.
PG  - 468-72
AB  - Multiple endocrine neoplasia type 1 (MEN1), an autosomal dominant disease 
      characterized by neoplasia of the parathyroid glands, anterior pituitary and 
      endocrine pancreas, is rarely reported in Asian populations. The MEN1 gene, 
      mapped to chromosome 11q13 but yet to be cloned, has been found to be homogeneous 
      in Caucasian populations through linkage analysis. Here, two previously 
      unreported Asian kindreds with MEN1 are described; linkage analysis using 
      microsatellite polymorphic markers in the MEN1 region was carried out. The first 
      kindred, of Mongolian-Chinese origin, is a multigeneration family with over 150 
      living members, eight of whom are affected to date. The second kindred is of 
      Chinese origin consisting of four affected members. Linkage to chromosome 11q13 
      was confirmed in both kindreds, supporting evidence for genetic homogeneity. A 
      recombination in the larger kindred localizes the gene distal to marker D11S956, 
      consistent with its placement from previous studies. We also show that it is 
      feasible to use these markers for predictive testing, as four gene carriers were 
      detected in 13 family members with unknown disease status in the first kindred.
FAU - Teh, B T
AU  - Teh BT
AD  - Department of Diabetes and Endocrinology, Princess Alexandra Hospital. 
      Woolloongabba, Australia.
FAU - Hii, S I
AU  - Hii SI
FAU - David, R
AU  - David R
FAU - Parameswaran, V
AU  - Parameswaran V
FAU - Grimmond, S
AU  - Grimmond S
FAU - Walters, M K
AU  - Walters MK
FAU - Tan, T T
AU  - Tan TT
FAU - Nancarrow, D J
AU  - Nancarrow DJ
FAU - Chan, S P
AU  - Chan SP
FAU - Mennon, J
AU  - Mennon J
AU  - et al.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Hum Genet
JT  - Human genetics
JID - 7613873
SB  - IM
GS  - MEN1
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Asian People/*genetics
MH  - Carcinoid Tumor/genetics
MH  - Child
MH  - Chromosomes, Human, Pair 11
MH  - Endocrine Gland Neoplasms/*genetics
MH  - Female
MH  - Genetic Testing
MH  - Humans
MH  - *Lod Score
MH  - Malaysia
MH  - Male
MH  - Multiple Endocrine Neoplasia Type 1/ethnology/*genetics
MH  - Pedigree
MH  - Polymorphism, Genetic
EDAT- 1994/11/01 00:00
MHDA- 1994/11/01 00:01
CRDT- 1994/11/01 00:00
PHST- 1994/11/01 00:00 [pubmed]
PHST- 1994/11/01 00:01 [medline]
PHST- 1994/11/01 00:00 [entrez]
AID - 10.1007/BF00211009 [doi]
PST - ppublish
SO  - Hum Genet. 1994 Nov;94(5):468-72. doi: 10.1007/BF00211009.