PMID- 7960221
OWN - NLM
STAT- MEDLINE
DCOM- 19941208
LR  - 20190708
IS  - 0020-7136 (Print)
IS  - 0020-7136 (Linking)
VI  - 59
IP  - 4
DP  - 1994 Nov 15
TI  - HLA-DQB1*0301 association with increased cutaneous melanoma risk.
PG  - 510-3
AB  - Susceptibility to a variety of malignancies has been linked to human leukocyte 
      antigen (HLA) genes, including the HLA class II allele DQB1*0301. To determine 
      whether melanoma risk is associated with HLA class II alleles, molecular 
      oligotyping of HLA class II-DRB1, -DQA1 and -DQB1 genes was performed for 45 
      patients with melanoma. The DQB1*0301 allele was present in 56% of melanoma 
      patients vs. 27% of 200 local Caucasian controls. This difference was highly 
      significant (Bonferroni's-corrected chi-square p = 0.003, OR = 3.4). No other 
      class II allele tested was present at significantly increased or decreased 
      frequency in melanoma patients. Furthermore, presence of DQB1*0301 in melanoma 
      patients was associated with advanced disease. Melanoma patients carrying the 
      DQB1*0301 allele presented on average with thicker primary tumors (mean 3.7 mm 
      vs. 1.8 mm, 2-tailed p = 0.02) and were more likely to present with regional or 
      distant metastatic disease (stages III-IV, 44% vs. 5%, chi-square p = 0.003), 
      compared to melanoma patients without DQB1*0301. Risk of melanoma incidence or 
      progression may be influenced by DQB1*0301 or a closely linked gene.
FAU - Lee, J E
AU  - Lee JE
AD  - Department of General Surgery, University of Texas M.D. Anderson Cancer Center, 
      Houston 77030.
FAU - Reveille, J D
AU  - Reveille JD
FAU - Ross, M I
AU  - Ross MI
FAU - Platsoucas, C D
AU  - Platsoucas CD
LA  - eng
GR  - CA52308/CA/NCI NIH HHS/United States
GR  - CA57884/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Int J Cancer
JT  - International journal of cancer
JID - 0042124
RN  - 0 (DNA Primers)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (Oligonucleotide Probes)
SB  - IM
GS  - HLA-DQB1*0301
MH  - Alleles
MH  - Base Sequence
MH  - Chi-Square Distribution
MH  - DNA Primers
MH  - Female
MH  - *Genes, MHC Class II
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DQ beta-Chains
MH  - Humans
MH  - Male
MH  - Melanoma/*genetics/immunology
MH  - Molecular Sequence Data
MH  - Oligonucleotide Probes
MH  - Polymerase Chain Reaction
MH  - Risk Factors
MH  - Sex Ratio
MH  - Skin Neoplasms/*genetics/immunology
EDAT- 1994/11/15 00:00
MHDA- 1994/11/15 00:01
CRDT- 1994/11/15 00:00
PHST- 1994/11/15 00:00 [pubmed]
PHST- 1994/11/15 00:01 [medline]
PHST- 1994/11/15 00:00 [entrez]
AID - 10.1002/ijc.2910590413 [doi]
PST - ppublish
SO  - Int J Cancer. 1994 Nov 15;59(4):510-3. doi: 10.1002/ijc.2910590413.