PMID- 7960983
OWN - NLM
STAT- MEDLINE
DCOM- 19941215
LR  - 20190708
IS  - 0360-3016 (Print)
IS  - 0360-3016 (Linking)
VI  - 30
IP  - 4
DP  - 1994 Nov 15
TI  - Consequences of two different doses to the lungs during a single dose of total 
      body irradiation: results of a randomized study on 85 patients.
PG  - 821-4
AB  - PURPOSE: To evaluate the incidence of lung complications and leukemia recurrences 
      after two different doses to the lungs during total body irradiation. METHODS AND 
      MATERIALS: Seventy-nine patients with acute leukemia (AML or ALL) in first 
      complete remission or chronic myeloid leukemia in the chronic phase, five 
      patients with high grade lymphoma, and one with chronic lymphocytic leukemia were 
      entered in the study. They were given a single dose of total body irradiation (10 
      Gy over 4 h) with two different doses to the lungs (6 Gy or 8 Gy) prior to bone 
      marrow transplantation. The median dose rate was 0.04 Gy/min. The median 
      follow-up for both groups of patients was 24 months. RESULTS: The actuarial 
      5-year overall survival rate was similar in both groups, 59% and 43% for patients 
      given 8 Gy and 6 Gy to the lungs, respectively. The lung complication rate was 
      similar in the two groups (28% vs. 22% for the 8 Gy and 6 Gy group, 
      respectively). The actuarial leukemia recurrence rate was significantly higher in 
      the group of patients given 6 Gy to the lungs (25%) vs. 0% in the 8 Gy group. 
      Interestingly, all recurrences occurred in the group of patients who were given 6 
      Gy to the lungs, who had acute leukemia, and no chronic graft vs. host disease 
      (GVHD). CONCLUSIONS: Although the number of patients was not very large and the 
      follow-up relatively short, these findings suggest that a lower dose to the lungs 
      could lead to an increased incidence of leukemia recurrences due to a lower dose 
      to the thoracic wall or to lower incidence of chronic GVHD.
FAU - Girinsky, T
AU  - Girinsky T
AD  - Institut Gustave-Roussy, Villejuif, France.
FAU - Socie, G
AU  - Socie G
FAU - Ammarguellat, H
AU  - Ammarguellat H
FAU - Cosset, J M
AU  - Cosset JM
FAU - Briot, E
AU  - Briot E
FAU - Bridier, A
AU  - Bridier A
FAU - Gluckman, E
AU  - Gluckman E
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Int J Radiat Oncol Biol Phys
JT  - International journal of radiation oncology, biology, physics
JID - 7603616
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Bone Marrow Transplantation
MH  - Child
MH  - Child, Preschool
MH  - Combined Modality Therapy
MH  - Cytomegalovirus Infections/etiology
MH  - Dose-Response Relationship, Radiation
MH  - Graft vs Host Disease/etiology
MH  - Humans
MH  - Leukemia/chemically induced/*radiotherapy/therapy
MH  - Leukemia, Lymphocytic, Chronic, B-Cell/complications/radiotherapy/therapy
MH  - Leukemia, Myeloid, Acute/complications/radiotherapy/therapy
MH  - Leukemia, Myeloid, Chronic-Phase/complications/radiotherapy/therapy
MH  - Lung/microbiology/*radiation effects
MH  - Lung Diseases, Interstitial/etiology/microbiology
MH  - Lung Neoplasms/*etiology
MH  - Middle Aged
MH  - Neoplasms, Radiation-Induced/*etiology
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/complications/radiotherapy/therapy
MH  - Whole-Body Irradiation/*adverse effects
EDAT- 1994/11/15 00:00
MHDA- 1994/11/15 00:01
CRDT- 1994/11/15 00:00
PHST- 1994/11/15 00:00 [pubmed]
PHST- 1994/11/15 00:01 [medline]
PHST- 1994/11/15 00:00 [entrez]
AID - 0360-3016(94)90355-7 [pii]
AID - 10.1016/0360-3016(94)90355-7 [doi]
PST - ppublish
SO  - Int J Radiat Oncol Biol Phys. 1994 Nov 15;30(4):821-4. doi: 
      10.1016/0360-3016(94)90355-7.