PMID- 7961181 OWN - NLM STAT- MEDLINE DCOM- 19941208 LR - 20190821 IS - 0378-5955 (Print) IS - 0378-5955 (Linking) VI - 78 IP - 1 DP - 1994 Jul TI - Auditory cortical responses in humans with congenital unilateral conductive hearing loss. PG - 91-7 AB - We recorded auditory evoked magnetic fields from 6 patients with congenital unilateral conductive hearing disorder with a 122-channel whole-head neuromagnetometer. The stimuli were 50-ms 1-kHz tones delivered to the better ear at interstimulus intervals (ISIs) of 2 and 8 s at two different intensities (50 and 70 dB HL). As in normal-hearing subjects, the amplitudes of N100m, the 100-ms response, were larger in 5 patients and the latencies were shorter in 3 patients over the hemisphere contralateral to stimulation. However, in one patient N100m peaked already at 61 ms over the contralateral hemisphere and amplitudes were larger over the ipsilateral hemisphere, possibly reflecting reorganization of the auditory pathways. In 3 patients the latencies were shorter over the ipsilateral hemisphere. The effects of ISI and intensity were similar over both hemispheres and did not differ from those in controls. It seems that congenital unilateral conductive hearing loss does not necessarily lead to any gross disturbances in the human auditory cortex. FAU - Vasama, J P AU - Vasama JP AD - Low Temperature Laboratory, Helsinki University of Technology, Espoo, Finland. FAU - Makela, J P AU - Makela JP FAU - Parkkonen, L AU - Parkkonen L FAU - Hari, R AU - Hari R LA - eng PT - Comparative Study PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - Netherlands TA - Hear Res JT - Hearing research JID - 7900445 SB - IM MH - Acoustic Stimulation MH - Adolescent MH - Adult MH - Auditory Cortex/pathology/*physiology MH - Auditory Threshold/physiology MH - Child MH - Ear Canal/*abnormalities MH - Ear, External/abnormalities MH - Ear, Middle/*abnormalities MH - Electromagnetic Fields MH - Evoked Potentials, Auditory/physiology MH - Female MH - Hearing Loss, Conductive/congenital/*physiopathology MH - Humans MH - Magnetics MH - Male EDAT- 1994/07/01 00:00 MHDA- 1994/07/01 00:01 CRDT- 1994/07/01 00:00 PHST- 1994/07/01 00:00 [pubmed] PHST- 1994/07/01 00:01 [medline] PHST- 1994/07/01 00:00 [entrez] AID - 0378-5955(94)90047-7 [pii] AID - 10.1016/0378-5955(94)90047-7 [doi] PST - ppublish SO - Hear Res. 1994 Jul;78(1):91-7. doi: 10.1016/0378-5955(94)90047-7.