PMID- 7963266
OWN - NLM
STAT- MEDLINE
DCOM- 19941221
LR  - 20190909
IS  - 0165-1838 (Print)
IS  - 0165-1838 (Linking)
VI  - 49
IP  - 1
DP  - 1994 Sep
TI  - Involvement of muscarinic M1 receptor in the central pathway of the 
      serotonin-induced Bezold-Jarisch reflex in rats.
PG  - 61-8
AB  - The involvement of central muscarinic receptors in mediating the Bezold-Jarisch 
      reflex elicited by injection of 5-hydroxytryptamine (5-HT) was studied in 
      urethane/chloralose-anesthetized rats. Intravenous bolus injection of 5-HT (3.1 
      to 50 micrograms/kg) evoked a short-lasting dose-related bradycardia and 
      hypotension, the Bezold-Jarisch reflex, accompanied with bursts of the efferent 
      cervical vagus nerve. Systemic administration of atropine (0.1 and 1 mg/kg) 
      blocked not only the cardiac responses but also the efferent cervical vagus nerve 
      activity changes. Although the afferent cervical vagus nerve was also activated 
      by an intravenous bolus injection of 5-HT, these responses were not altered by 
      the systemic administration of even a high dose of atropine (1 mg/kg). 
      Intracerebroventricular (i.c.v.) administration of pirenzepine (1 and 10 
      micrograms/10 microliters), a selective M1 receptor antagonist, caused a 
      rightward shift of the 5-HT dose-response curve for efferent vagus nerve 
      activity. In contrast, i.c.v. administration of muscarinic type 2 receptor 
      antagonist, gallamine, and type 3 receptor antagonist, 
      p-fluorohexahydrosiladifenidol, failed to alter the response in nerve activity to 
      5-HT. These results suggest that the activation of central nervous muscarinic 
      receptors might be involved in mediating the Bezold-Jarisch reflex and that the 
      subtype might belong to type 1.
FAU - Saito, K
AU  - Saito K
AD  - Department of Cardiovascular Medicine, Hokkaido University School of Medicine, 
      Sapporo, Japan.
FAU - Yoshioka, M
AU  - Yoshioka M
FAU - Kohya, T
AU  - Kohya T
FAU - Kitabatake, A
AU  - Kitabatake A
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - J Auton Nerv Syst
JT  - Journal of the autonomic nervous system
JID - 8003419
RN  - 0 (Muscarinic Antagonists)
RN  - 0 (Receptors, Muscarinic)
RN  - 333DO1RDJY (Serotonin)
RN  - 7C0697DR9I (Atropine)
SB  - IM
MH  - Animals
MH  - Atropine/administration & dosage/pharmacology
MH  - Heart Rate/drug effects
MH  - Hemodynamics/drug effects/physiology
MH  - Injections, Intraventricular
MH  - Male
MH  - Muscarinic Antagonists
MH  - Neural Pathways/drug effects/physiology
MH  - Neurons, Efferent/drug effects
MH  - Rats
MH  - Rats, Wistar
MH  - Receptors, Muscarinic/*physiology
MH  - Reflex/*drug effects
MH  - Serotonin/*pharmacology
MH  - Vagus Nerve/drug effects/physiology
EDAT- 1994/09/01 00:00
MHDA- 1994/09/01 00:01
CRDT- 1994/09/01 00:00
PHST- 1994/09/01 00:00 [pubmed]
PHST- 1994/09/01 00:01 [medline]
PHST- 1994/09/01 00:00 [entrez]
AID - 0165-1838(94)90021-3 [pii]
AID - 10.1016/0165-1838(94)90021-3 [doi]
PST - ppublish
SO  - J Auton Nerv Syst. 1994 Sep;49(1):61-8. doi: 10.1016/0165-1838(94)90021-3.