PMID- 7963718
OWN - NLM
STAT- MEDLINE
DCOM- 19941201
LR  - 20190512
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 170
IP  - 5
DP  - 1994 Nov
TI  - Enhancement of intracellular growth of Mycobacterium tuberculosis in human 
      monocytes by transforming growth factor-beta 1.
PG  - 1229-37
AB  - The production of transforming growth factor-beta (TGF beta 1) by human monocytes 
      (MN) infected with Mycobacterium tuberculosis and its effects on the 
      intracellular fate of the organism were studied. M. tuberculosis infection of MN 
      induced both expression of mRNA and secretion of tumor necrosis factor-alpha (TNF 
      alpha) and TGF beta 1 protein. Neutralizing antibody to TGF beta 1 reduced the 
      intracellular growth of M. tuberculosis. The growth-enhancing effects of TGF beta 
      1 could not be explained by increased initial bacterial load. Preculture with TGF 
      beta 1 decreased uptake of M. tuberculosis. Exposure of MN to increasing 
      concentrations of TGF beta 1 before or after infection with M. tuberculosis 
      accelerated intracellular bacterial replication. Both TNF alpha and 
      interferon-gamma (IFN-gamma) limited mycobacterial replication. TGF beta 1 (10 
      ng/mL) abrogated the bacteriostatic effects of TNF alpha and IFN-gamma. Within 
      the infected focus, TGF beta 1 produced by mononuclear phagocytes may play an 
      important role in the pathogenesis of tuberculosis, in part by modulating the 
      response to potentially protective cytokines such as TNF alpha and IFN-gamma.
FAU - Hirsch, C S
AU  - Hirsch CS
AD  - Department of Medicine, Case Western Reserve University, University Hospitals of 
      Cleveland.
FAU - Yoneda, T
AU  - Yoneda T
FAU - Averill, L
AU  - Averill L
FAU - Ellner, J J
AU  - Ellner JJ
FAU - Toossi, Z
AU  - Toossi Z
LA  - eng
GR  - AI-18471/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (Transforming Growth Factor beta)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Humans
MH  - Interferon-gamma/pharmacology
MH  - Monocytes/metabolism/*microbiology
MH  - Mycobacterium tuberculosis/*drug effects/growth & development
MH  - Phagocytosis/drug effects
MH  - Transforming Growth Factor beta/biosynthesis/*pharmacology
MH  - Tumor Necrosis Factor-alpha/biosynthesis/pharmacology
MH  - Virus Replication/drug effects
EDAT- 1994/11/01 00:00
MHDA- 1994/11/01 00:01
CRDT- 1994/11/01 00:00
PHST- 1994/11/01 00:00 [pubmed]
PHST- 1994/11/01 00:01 [medline]
PHST- 1994/11/01 00:00 [entrez]
AID - 10.1093/infdis/170.5.1229 [doi]
PST - ppublish
SO  - J Infect Dis. 1994 Nov;170(5):1229-37. doi: 10.1093/infdis/170.5.1229.