PMID- 7965501
OWN - NLM
STAT- MEDLINE
DCOM- 19941215
LR  - 20190710
IS  - 0022-3468 (Print)
IS  - 0022-3468 (Linking)
VI  - 29
IP  - 8
DP  - 1994 Aug
TI  - Effect of maternal ethanol intake on fetal rabbit gastrointestinal development.
PG  - 1030-3; discussion 1033-4
AB  - Maternal ingestion of alcohol is believed to be one factor that greatly 
      influences the development of intrauterine growth retardation (IUGR) and 
      postnatal growth failure. The present study was undertaken to determine whether 
      maternally ingested alcohol adversely affects fetal growth and intestinal mucosal 
      function. Five time-mated New Zealand white rabbit does were given ethanol 
      intravenously (ETH group) (30% vol/vol; 1.0 g/kg/d) on gestational days (GD) 15 
      through 29 (term, 31 days). Two other rabbits received the same dose of ethanol. 
      Maternal, fetal, and amniotic fluid alcohol levels were measured on GD 24. Four 
      control rabbits (SH group) received normal saline (25 mL, intravenously). At 
      term, the animals were delivered by cesarean section and killed. Seventeen of the 
      42 ETH fetuses survived the study period (43%); all 24 SH fetuses survived. On GD 
      24, within 60 minutes after maternal ethanol infusion, the fetal blood alcohol 
      concentration (BAC) increased to 153 +/- 1.97 mg/dL (v maternal, 179 +/- 1.75 
      mg/dL); the amniotic ethanol level increased to 46 +/- 1.32 mg/dL. Birth weight 
      was lower in the ETH group (46.88 +/- 2.21 g) than in the SH group (55.78 +/- 
      1.80 g) (P < .01). Disaccharidase activity, an indicator of intestinal mucosal 
      function, showed that lactase activity (per milligram of protein) was 
      significantly lower in ETH fetuses (2.60 x 10(-2) +/- 0.22 UE/mg) than in SH 
      fetuses (3.50 x 10(-2) +/- 0.25 UE/mg) (P = .01); maltase activity and protein 
      content were not affected significantly. This report provides the first 
      description of the adverse effects of maternal alcohol ingestion on the small 
      intestinal mucosal function of the fetal rabbit.
FAU - Guo, W
AU  - Guo W
AD  - Division of Pediatric Surgery, UCLA School of Medicine 90024-690318.
FAU - Gregg, J P
AU  - Gregg JP
FAU - Fonkalsrud, E W
AU  - Fonkalsrud EW
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Pediatr Surg
JT  - Journal of pediatric surgery
JID - 0052631
RN  - 3K9958V90M (Ethanol)
RN  - EC 3.2.1.- (Disaccharidases)
SB  - IM
MH  - Alcohol Drinking/adverse effects
MH  - Amniotic Fluid/chemistry
MH  - Animals
MH  - Birth Weight/drug effects
MH  - Digestive System/drug effects/embryology
MH  - Disaccharidases/metabolism
MH  - Embryonic and Fetal Development/*drug effects
MH  - Ethanol/*adverse effects/blood
MH  - Female
MH  - Fetal Blood/chemistry
MH  - Fetal Growth Retardation/chemically induced
MH  - Intestinal Mucosa/*drug effects
MH  - Intestine, Small/*drug effects
MH  - Rabbits
EDAT- 1994/08/01 00:00
MHDA- 1994/08/01 00:01
CRDT- 1994/08/01 00:00
PHST- 1994/08/01 00:00 [pubmed]
PHST- 1994/08/01 00:01 [medline]
PHST- 1994/08/01 00:00 [entrez]
AID - 0022-3468(94)90273-9 [pii]
AID - 10.1016/0022-3468(94)90273-9 [doi]
PST - ppublish
SO  - J Pediatr Surg. 1994 Aug;29(8):1030-3; discussion 1033-4. doi: 
      10.1016/0022-3468(94)90273-9.