PMID- 7965726
OWN - NLM
STAT- MEDLINE
DCOM- 19941125
LR  - 20131121
IS  - 0022-3565 (Print)
IS  - 0022-3565 (Linking)
VI  - 271
IP  - 1
DP  - 1994 Oct
TI  - Age modulates the long-term but not the acute effects of the serotonergic 
      neurotoxicant 3,4-methylenedioxymethamphetamine.
PG  - 285-93
AB  - Tissue levels of serotonin (5-HT), levels of its metabolite 5-hydroxyindoleacetic 
      acid (5-HIAA) and populations of 5-HT reuptake sites were measured in the brains 
      of rats exposed to 3,4-methylenedioxymethamphetamine (MDMA) at selected 
      developmental ages. MDMA exposure at postnatal day (PND) 10 did not result in 
      altered 5-HT or 5-HIAA levels 1 week after administration in any brain region 
      examined. However, MDMA exposure at PND 40 and PND 70 resulted in dose-dependent 
      reductions in 5-HT and 5-HIAA levels at 1 week in all brain regions examined. 
      Time course studies revealed that at PND 10, MDMA acutely (< or = 24 hr) reduced 
      5-HT levels and that these levels later recovered to control levels. MDMA also 
      acutely reduced 5-HT levels at PND 40 and PND 70, but at these ages the 5-HT 
      levels were persistently depressed ( > or = 72 hr). Time course studies also 
      revealed that MDMA acutely elevated dopamine levels in caudate putamen at PND 40 
      and PND 70, but no alterations in dopamine levels were observed at PND 10. 
      Analysis of 5-HT reuptake site populations revealed that at PND 10 and PND 40, 
      MDMA had little effect on reuptake site populations. At PND 70, however, MDMA 
      reduced 5-HT reuptake site populations as early as 24 hr after administration. 
      These experiments demonstrate not only that the biochemical effects of MDMA 
      exposure are altered by the developmental status of the experimental animal, but 
      also that each individual biochemical component may show differing sensitivities 
      to alteration by MDMA at different developmental ages.
FAU - Broening, H W
AU  - Broening HW
AD  - Interdisciplinary Toxicology Program, University of Arkansas for Medical 
      Sciences, Little Rock.
FAU - Bacon, L
AU  - Bacon L
FAU - Slikker, W Jr
AU  - Slikker W Jr
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Pharmacol Exp Ther
JT  - The Journal of pharmacology and experimental therapeutics
JID - 0376362
RN  - 333DO1RDJY (Serotonin)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Body Temperature/drug effects
MH  - Brain/*drug effects/metabolism
MH  - Dopamine/analysis
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*toxicity
MH  - Pregnancy
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Serotonin/*analysis/metabolism
EDAT- 1994/10/01 00:00
MHDA- 2001/03/28 10:01
CRDT- 1994/10/01 00:00
PHST- 1994/10/01 00:00 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1994/10/01 00:00 [entrez]
PST - ppublish
SO  - J Pharmacol Exp Ther. 1994 Oct;271(1):285-93.