PMID- 7966645
OWN - NLM
STAT- MEDLINE
DCOM- 19941212
LR  - 20200724
IS  - 0022-538X (Print)
IS  - 1098-5514 (Electronic)
IS  - 0022-538X (Linking)
VI  - 68
IP  - 12
DP  - 1994 Dec
TI  - Correlation between precolonization of trigeminal ganglia by attenuated strains 
      of pseudorabies virus and resistance to wild-type virus latency.
PG  - 8470-6
AB  - We compared the levels of latent pseudorabies virus (PRV) DNA in trigeminal 
      ganglia (TG) of pigs after intranasal inoculation of different PRV strains by 
      using quantitative DNA PCR. The extent of colonization attained in each case 
      varied significantly according to the type of strain and inoculum dose, wild-type 
      (WT) PRV being the most efficient strain in colonizing TG. When groups of pigs 
      representing different levels of precolonization of TG with an attenuated PRV 
      strain were challenged with WT PRV, it became evident that there is a 
      statistically significant inverse correlation between the extent of 
      precolonization attained by an attenuated PRV strain in TG and the level of 
      establishment of latency by superinfecting WT PRV. The protection against WT PRV 
      latency did not correlate with the extent of WT PRV replication at the portal of 
      entry.
FAU - Schang, L M
AU  - Schang LM
AD  - Department of Veterinary & Biomedical Sciences, University of Nebraska-Lincoln 
      68583-0905.
FAU - Kutish, G F
AU  - Kutish GF
FAU - Osorio, F A
AU  - Osorio FA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - J Virol
JT  - Journal of virology
JID - 0113724
RN  - 0 (DNA Primers)
RN  - 0 (DNA, Viral)
RN  - 0 (Oligonucleotide Probes)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Base Sequence
MH  - DNA Primers
MH  - DNA, Viral/analysis
MH  - Herpesvirus 1, Suid/genetics/pathogenicity/*physiology
MH  - Molecular Sequence Data
MH  - Oligonucleotide Probes
MH  - Pharynx/virology
MH  - Polymerase Chain Reaction/methods
MH  - Swine
MH  - Time Factors
MH  - Trigeminal Ganglion/*virology
MH  - *Virus Latency
MH  - Virus Replication
MH  - Virus Shedding
PMC - PMC237325
EDAT- 1994/12/01 00:00
MHDA- 1994/12/01 00:01
PMCR- 1994/12/01
CRDT- 1994/12/01 00:00
PHST- 1994/12/01 00:00 [pubmed]
PHST- 1994/12/01 00:01 [medline]
PHST- 1994/12/01 00:00 [entrez]
PHST- 1994/12/01 00:00 [pmc-release]
AID - 10.1128/JVI.68.12.8470-8476.1994 [doi]
PST - ppublish
SO  - J Virol. 1994 Dec;68(12):8470-6. doi: 10.1128/JVI.68.12.8470-8476.1994.