PMID- 7966782
OWN - NLM
STAT- MEDLINE
DCOM- 19941229
LR  - 20061115
IS  - 0022-5347 (Print)
IS  - 0022-5347 (Linking)
VI  - 153
IP  - 1
DP  - 1995 Jan
TI  - Mapping of regions of physical deletion on chromosome 16q in prostate cancer 
      cells by fluorescence in situ hybridization (FISH).
PG  - 249-54
AB  - Recent evidence suggests that a tumor suppressor gene important in the 
      progression of prostatic carcinoma may reside on chromosome 16q. The exact 
      location and identity of this gene are unknown. We used fluorescence in situ 
      hybridization in a novel manner to define more clearly the location of this gene. 
      Region-specific chromosome 16 cosmid contig probes were hybridized directly to 
      interphase prostatic carcinoma nuclei in order to measure physical deletion of 
      chromosomal loci. Fifteen of 30 tumors (50%) showed evidence of physical deletion 
      of 16q24. Other probes were used to test for regions of chromosome 16 deletions 
      in the same specimens, and a map showing a region of common deletion was created. 
      This map showed the proximal terminus of the region of common deletion to be 
      located distal to 16q23.1. These data correlate well with loss of heterozygosity 
      data in the literature and provide further evidence for the presence of a 
      prostatic carcinoma tumor suppressor gene on chromosome 16q.
FAU - Cher, M L
AU  - Cher ML
AD  - Department of Urology, University of California School of Medicine, San Francisco 
      94143-0738.
FAU - Ito, T
AU  - Ito T
FAU - Weidner, N
AU  - Weidner N
FAU - Carroll, P R
AU  - Carroll PR
FAU - Jensen, R H
AU  - Jensen RH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Urol
JT  - The Journal of urology
JID - 0376374
SB  - IM
MH  - *Chromosome Deletion
MH  - Chromosome Mapping/*methods
MH  - *Chromosomes, Human, Pair 16
MH  - Genes, Suppressor
MH  - Humans
MH  - *In Situ Hybridization, Fluorescence
MH  - Male
MH  - Prostatic Neoplasms/*genetics
EDAT- 1995/01/01 00:00
MHDA- 1995/01/01 00:01
CRDT- 1995/01/01 00:00
PHST- 1995/01/01 00:00 [pubmed]
PHST- 1995/01/01 00:01 [medline]
PHST- 1995/01/01 00:00 [entrez]
AID - S0022-5347(01)67900-X [pii]
AID - 10.1097/00005392-199501000-00086 [doi]
PST - ppublish
SO  - J Urol. 1995 Jan;153(1):249-54. doi: 10.1097/00005392-199501000-00086.