PMID- 7968583
OWN - NLM
STAT- MEDLINE
DCOM- 19941229
LR  - 20190512
IS  - 0267-8357 (Print)
IS  - 0267-8357 (Linking)
VI  - 9
IP  - 4
DP  - 1994 Jul
TI  - A deficiency for nucleotide excision repair strongly potentiates the mutagenic 
      effectiveness of methyl bromide in Drosophila.
PG  - 387-9
AB  - A DNA repair assay measuring hypermutability response in the absence of 
      nucleotide excision repair (NER) was employed to study the impact of a deficiency 
      in NER on the induction of forward mutations (X-chromosomal recessive lethals) by 
      methyl bromide (MeBr) in Drosophila melanogaster. Postmeiotic male germ-cell 
      stages reacted with MeBr were introduced in either NER competent oocytes (exr+) 
      or in cells from the NER- strain mus-201. The high average M(exr-)/M(exr+) 
      hypermutability ratio of 8.3 determined for MeBr is similar to the 
      M(exr-)/M(exr+) indices found for other monofunctional alkylating agents with 
      high Swain-Scott s values, such as methyl methanesulphonate and dimethyl 
      sulphate. It is concluded that the genotoxic profile of methyl bromide is in 
      keeping with those of high s-value alkylating agents but it seems incompatible 
      with a methylating agent producing substantial amounts of O6 methylguanine.
FAU - Ballering, L A
AU  - Ballering LA
AD  - Department of Radiation Genetics and Chemical Mutagenesis, Medical Genetics 
      Centre South-West Netherlands-MGC, Sylvius Laboratories, Leiden.
FAU - Nivard, M J
AU  - Nivard MJ
FAU - Vogel, E W
AU  - Vogel EW
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Mutagenesis
JT  - Mutagenesis
JID - 8707812
RN  - 0 (Alkylating Agents)
RN  - 0 (Carcinogens)
RN  - 0 (Hydrocarbons, Brominated)
RN  - 5Z93L87A1R (Guanine)
RN  - 9B710FV2AE (O-(6)-methylguanine)
RN  - 9V42E1Z7B6 (methyl bromide)
SB  - IM
MH  - Alkylating Agents/toxicity
MH  - Animals
MH  - Carcinogens/toxicity
MH  - DNA Damage
MH  - DNA Repair/*genetics
MH  - Drosophila melanogaster/*drug effects/genetics
MH  - Female
MH  - Genes, Lethal
MH  - Genes, Recessive
MH  - Guanine/analogs & derivatives/analysis
MH  - Hydrocarbons, Brominated/*toxicity
MH  - Male
MH  - *Mutagenicity Tests
MH  - Spermatozoa/drug effects
MH  - X Chromosome
EDAT- 1994/07/01 00:00
MHDA- 1994/07/01 00:01
CRDT- 1994/07/01 00:00
PHST- 1994/07/01 00:00 [pubmed]
PHST- 1994/07/01 00:01 [medline]
PHST- 1994/07/01 00:00 [entrez]
AID - 10.1093/mutage/9.4.387 [doi]
PST - ppublish
SO  - Mutagenesis. 1994 Jul;9(4):387-9. doi: 10.1093/mutage/9.4.387.