PMID- 7968694
OWN - NLM
STAT- MEDLINE
DCOM- 19941216
LR  - 20190821
IS  - 0385-5600 (Print)
IS  - 0385-5600 (Linking)
VI  - 38
IP  - 7
DP  - 1994
TI  - Prevalence of human herpesvirus 6 variants A and B in patients with chronic 
      fatigue syndrome.
PG  - 587-90
AB  - Peripheral blood mononuclear cells collected from 13 patients with chronic 
      fatigue syndrome and 13 healthy controls were analyzed for the presence of human 
      herpesvirus 6 (HHV-6) DNA by variant-specific polymerase chain reaction and dot 
      blot hybridization. HHV-6 DNA was detected in 7 of 13 (53%) patients, and of 
      those 7 patients, 4 were positive for HHV-6 variant A DNA and 3 were for variant 
      B. No HHV-6 DNA was detected in the controls. Serum antibody titers to the late 
      antigen and antibody prevalence to the early antigen of HHV-6 were significantly 
      higher in the patient group. These results suggest active replication of HHV-6 in 
      patients with chronic fatigue syndrome.
FAU - Yalcin, S
AU  - Yalcin S
AD  - Department of Virology, Osaka University Medical School, Japan.
FAU - Kuratsune, H
AU  - Kuratsune H
FAU - Yamaguchi, K
AU  - Yamaguchi K
FAU - Kitani, T
AU  - Kitani T
FAU - Yamanishi, K
AU  - Yamanishi K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Australia
TA  - Microbiol Immunol
JT  - Microbiology and immunology
JID - 7703966
RN  - 0 (Antibodies, Viral)
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Antibodies, Viral/blood
MH  - Base Sequence
MH  - DNA, Viral/*blood
MH  - Fatigue Syndrome, Chronic/*virology
MH  - Herpesvirus 6, Human/genetics/immunology/*isolation & purification/physiology
MH  - Humans
MH  - Leukocytes, Mononuclear/*virology
MH  - Molecular Sequence Data
MH  - Nucleic Acid Hybridization
MH  - Polymerase Chain Reaction
MH  - Virus Replication
EDAT- 1994/01/01 00:00
MHDA- 1994/01/01 00:01
CRDT- 1994/01/01 00:00
PHST- 1994/01/01 00:00 [pubmed]
PHST- 1994/01/01 00:01 [medline]
PHST- 1994/01/01 00:00 [entrez]
AID - 10.1111/j.1348-0421.1994.tb01827.x [doi]
PST - ppublish
SO  - Microbiol Immunol. 1994;38(7):587-90. doi: 10.1111/j.1348-0421.1994.tb01827.x.