PMID- 7968940
OWN - NLM
STAT- MEDLINE
DCOM- 19941220
LR  - 20190920
IS  - 0892-0362 (Print)
IS  - 0892-0362 (Linking)
VI  - 16
IP  - 4
DP  - 1994 Jul-Aug
TI  - Effects of acute ethanol intoxication during pregnancy on central dopaminergic 
      system in male rats.
PG  - 385-9
AB  - Pregnant albino rats received 2 IP injections, spaced by 4 h, of either ethanol 
      (2.9 g/kg in 24% v/v saline solution) or saline, on gestational day (GD) 8. 
      During adulthood, male rats prenatally exposed to alcohol exhibited an increased 
      stereotyped behavioral response to 12 mg/kg of amphetamine (AMPH) or 1 mg/kg of 
      apomorphine (APO), whereas the stereotypy induced by 6 mg/kg of AMPH showed no 
      difference between control and experimental animals. Also, the hypoactivity 
      response elicited by small doses of APO was not significantly affected by the 
      prenatal treatment with alcohol. Analysis of dopaminergic function in the 
      striatum and nucleus accumbens demonstrated no change on dopamine (DA) levels in 
      both structures in alcohol pre-exposed 55- and 180-day-old rats. A reduction in 
      striatum 3-4 dihydroxyphenylacetic acid levels was observed at both ages. These 
      results indicate that an acute intoxication with alcohol on GD 8 induces a 
      long-lasting decrease in striatal but not in nucleus accumbens DA metabolism. As 
      a consequence, a lower striatal DA release might produce a compensatory 
      supersensitivity of postsynaptic DA sites. This interpretation is consistent and 
      correlates with behavioral results.
FAU - Fulginiti, S
AU  - Fulginiti S
AD  - Departamento de Farmacologia, Facultad de Ciencias Quimicas, Universidad Nacional 
      de Cordoba, Argentina.
FAU - Minetti, S A
AU  - Minetti SA
FAU - Virgolini, M B
AU  - Virgolini MB
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Neurotoxicol Teratol
JT  - Neurotoxicology and teratology
JID - 8709538
RN  - 102-32-9 (3,4-Dihydroxyphenylacetic Acid)
RN  - CK833KGX7E (Amphetamine)
RN  - N21FAR7B4S (Apomorphine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - 3,4-Dihydroxyphenylacetic Acid/metabolism
MH  - Aging/metabolism
MH  - *Alcoholic Intoxication
MH  - Amphetamine/pharmacology
MH  - Animals
MH  - Apomorphine/pharmacology
MH  - Corpus Striatum/drug effects/growth & development/*metabolism
MH  - Dopamine/*metabolism
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Gestational Age
MH  - Male
MH  - Motor Activity/*drug effects
MH  - Nucleus Accumbens/drug effects/growth & development/*metabolism
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Rats
MH  - Rats, Wistar
MH  - *Stereotyped Behavior/drug effects
MH  - Synapses/drug effects/metabolism
EDAT- 1994/07/01 00:00
MHDA- 1994/07/01 00:01
CRDT- 1994/07/01 00:00
PHST- 1994/07/01 00:00 [pubmed]
PHST- 1994/07/01 00:01 [medline]
PHST- 1994/07/01 00:00 [entrez]
AID - 0892-0362(94)90027-2 [pii]
AID - 10.1016/0892-0362(94)90027-2 [doi]
PST - ppublish
SO  - Neurotoxicol Teratol. 1994 Jul-Aug;16(4):385-9. doi: 
      10.1016/0892-0362(94)90027-2.