PMID- 7968943
OWN - NLM
STAT- MEDLINE
DCOM- 19941220
LR  - 20190920
IS  - 0892-0362 (Print)
IS  - 0892-0362 (Linking)
VI  - 16
IP  - 4
DP  - 1994 Jul-Aug
TI  - Effects of prenatal nicotine exposure on the morphogenesis of somatosensory 
      cortex.
PG  - 411-21
AB  - Human reports as well as animal studies have recorded accelerated motor activity, 
      learning, and memory deficits in offsprings of mothers exposed to nicotine during 
      pregnancy. Morphological correlation of these neurobehavioural defects has not 
      been done to date. Here, the cerebral cortex has been evaluated after prenatal 
      nicotine exposure. Groups of pregnant rats were injected IP with nicotine at 2.5 
      mg/kg/day dosage from gestational day (GD) 6 to term. Morphology of the 
      somatosensory cortex was analysed and compared with that of the control group up 
      to postnatal day (PND) 40. A significant reduction in body weight and brain 
      weight on PND 10 and 20, respectively was observed in nicotine exposed group as 
      compared to age matched controls. Morphometric analysis of the somatosensory 
      cortex showed a reduction in cortical thickness up to PND 20 and decreased cell 
      size at PND 10, 20, and 40 in nicotine-exposed brains. Neuronal density of Layer 
      5 of somatosensory cortex was greater at PND 20 and 40 in the experimental group. 
      Golgi staining of large pyramidal neurons of Layer 5 showed significantly 
      decreased dendritic branching and increased dendritic spine density in the 
      experimental group at all ages studied. Irregular arrangement of cisternae of 
      rough endoplasmic reticulum, paucity of free ribosomes, and frequent cytoplasmic 
      vacuoles were noted by electron microscopy in many neurons up to PND 40. A large 
      number of electron dense cells were observed in nicotine exposed brains at all 
      the time intervals studied. The morphological features of somatosensory cortex 
      observed after prenatal nicotine administration suggest that the drug delays 
      neuronal maturation and affects intracytoplasmic membrane systems.
FAU - Roy, T S
AU  - Roy TS
AD  - Department of Anatomy, All India Institute of Medical Sciences, New Delhi.
FAU - Sabherwal, U
AU  - Sabherwal U
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Neurotoxicol Teratol
JT  - Neurotoxicology and teratology
JID - 8709538
RN  - 6M3C89ZY6R (Nicotine)
SB  - IM
MH  - Aging/physiology
MH  - Animals
MH  - Body Weight/drug effects
MH  - Brain/drug effects/*growth & development
MH  - Female
MH  - Morphogenesis/drug effects
MH  - Neurons/cytology/*drug effects/pathology
MH  - Nicotine/*toxicity
MH  - Pregnancy
MH  - Pregnancy, Animal/*drug effects
MH  - *Prenatal Exposure Delayed Effects
MH  - Rats
MH  - Rats, Wistar
MH  - Reference Values
MH  - Somatosensory Cortex/cytology/*drug effects/pathology
MH  - Weight Gain/drug effects
EDAT- 1994/07/01 00:00
MHDA- 1994/07/01 00:01
CRDT- 1994/07/01 00:00
PHST- 1994/07/01 00:00 [pubmed]
PHST- 1994/07/01 00:01 [medline]
PHST- 1994/07/01 00:00 [entrez]
AID - 0892-0362(94)90030-2 [pii]
AID - 10.1016/0892-0362(94)90030-2 [doi]
PST - ppublish
SO  - Neurotoxicol Teratol. 1994 Jul-Aug;16(4):411-21. doi: 
      10.1016/0892-0362(94)90030-2.