PMID- 7969788
OWN - NLM
STAT- MEDLINE
DCOM- 19941223
LR  - 20181130
IS  - 0028-3835 (Print)
IS  - 0028-3835 (Linking)
VI  - 60
IP  - 3
DP  - 1994 Sep
TI  - Vasopressin mediates hypoglycemia-induced inhibition of luteinizing hormone 
      secretion in the ovariectomized rhesus monkey.
PG  - 297-304
AB  - The objective of the present study was to examine the role of vasopressin in the 
      regulation of LH secretion in the rhesus monkey. The effect of vasopressin 
      administration on basal LH secretion and vasopressin antagonism on stress-induced 
      inhibition of LH secretion were examined. Intracerebroventricular (i.c.v.) 
      infusion of vasopressin (20 micrograms/h) to chair restrained ovariectomized 
      rhesus monkeys (n = 5) decreased the area under the LH curve by -51.61 +/- 13.73 
      ng/ml/h compared to -8.35 +/- 7.11 ng/ml/h following infusion of artificial CSF 
      (aCSF; p = 0.021). This effect was independent of any change in mean arterial 
      pressure. Subsequently, the role of vasopressin in hypoglycemia-induced 
      suppression of LH was examined. Administration of insulin (1 U/kg BW) to 
      chair-restrained ovariectomized rhesus monkeys decreased the area under the LH 
      curve by -60.88 +/- 19.77 ng/ml/h. The decrease in LH was significantly different 
      from that observed in aCSF-infused euglycemic controls which exhibited a slight 
      decrease in LH (-8.35 +/- 7.11 ng/ml/h; p = 0.036). In contrast, the area under 
      the LH curve was increased slightly (1.42 +/- 11.93 ng/ml/h) when insulin 
      administration was combined with i.c.v. infusion of the vasopressin antagonist 
      [deaminopenicillamine1, O-methyl-tyrosine2, arginine8]-vasopressin (120 
      micrograms/h; p = 0.013 vs. insulin only). The demonstration that vasopressin 
      administration inhibits LH secretion whereas vasopressin antagonism prevents 
      hypoglycemia-induced LH suppression suggests that vasopressin is a physiological 
      inhibitor of LH secretion in the rhesus monkey.
FAU - Heisler, L E
AU  - Heisler LE
AD  - Department of Physiology, Queen's University, Kingston, Canada.
FAU - Tumber, A J
AU  - Tumber AJ
FAU - Reid, R L
AU  - Reid RL
FAU - van Vugt, D A
AU  - van Vugt DA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Neuroendocrinology
JT  - Neuroendocrinology
JID - 0035665
RN  - 0 (Insulin)
RN  - 11000-17-2 (Vasopressins)
RN  - 113-79-1 (Arginine Vasopressin)
RN  - 67269-08-3 (argipressin, deaminopenicillamine(1)-O-methyl-Tyr(2)-)
RN  - 9002-67-9 (Luteinizing Hormone)
SB  - IM
MH  - Animals
MH  - Arginine Vasopressin/analogs & derivatives/pharmacology
MH  - Blood Pressure
MH  - Cerebrospinal Fluid/physiology
MH  - Female
MH  - Hypoglycemia/chemically induced/*physiopathology
MH  - Insulin
MH  - Luteinizing Hormone/*metabolism
MH  - Macaca mulatta
MH  - *Ovariectomy
MH  - Vasopressins/administration & dosage/antagonists & inhibitors/*pharmacology
EDAT- 1994/09/01 00:00
MHDA- 1994/09/01 00:01
CRDT- 1994/09/01 00:00
PHST- 1994/09/01 00:00 [pubmed]
PHST- 1994/09/01 00:01 [medline]
PHST- 1994/09/01 00:00 [entrez]
AID - 10.1159/000126762 [doi]
PST - ppublish
SO  - Neuroendocrinology. 1994 Sep;60(3):297-304. doi: 10.1159/000126762.