PMID- 7971008
OWN - NLM
STAT- MEDLINE
DCOM- 19941227
LR  - 20220330
IS  - 0031-4005 (Print)
IS  - 0031-4005 (Linking)
VI  - 94
IP  - 6 Pt 1
DP  - 1994 Dec
TI  - Epidemiology of physician-diagnosed allergic rhinitis in childhood.
PG  - 895-901
AB  - OBJECTIVE: To investigate the natural history of and risk factors for allergic 
      rhinitis in the first 6 years of life. METHODS: Parents of 747 healthy children 
      followed from birth completed a questionnaire when the child was 6 years old. 
      Data were obtained regarding physician-diagnosed allergic rhinitis (PDAR), 
      associated symptoms, and age at onset. Risk-factor data were taken from earlier 
      questionnaires, and data regarding immunoglobulin E (IgE) and skin-test 
      reactivity were obtained at age 6. RESULTS: By the age of 6, 42% of children had 
      PDAR. Children whose rhinitis began in the first year of life had more 
      respiratory symptoms at age 6 and were more likely to have a diagnosis of asthma. 
      Early introduction of foods or formula, heavy maternal cigarette smoking in the 
      first year of life, and higher IgE, as well as parental allergic disorders, were 
      associated with early development of rhinitis. Risk factors for PDAR that 
      remained significant in a multivariate model included maternal history of 
      physician-diagnosed allergy (odds ratio: 2.2, 95% confidence interval: 
      1.35-3.54), asthma in the child (4.06, 2.06-7.99), and IgE greater than 100 IU/mL 
      at age 6 (1.93, 1.18-3.17). The odds for atopic as opposed to nonatopic PDAR were 
      significantly higher only among those with high IgE and those who had dogs. 
      CONCLUSION: Allergic rhinitis developing in the first years of life is an early 
      manifestation of an atopic predisposition, which may be triggered by early 
      environmental mental exposures.
FAU - Wright, A L
AU  - Wright AL
AD  - Department of Pediatrics, University of Arizona, Tucson.
FAU - Holberg, C J
AU  - Holberg CJ
FAU - Martinez, F D
AU  - Martinez FD
FAU - Halonen, M
AU  - Halonen M
FAU - Morgan, W
AU  - Morgan W
FAU - Taussig, L M
AU  - Taussig LM
LA  - eng
GR  - NHLBI 14136/HL/NHLBI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Pediatrics
JT  - Pediatrics
JID - 0376422
SB  - IM
MH  - Age of Onset
MH  - Arizona/epidemiology
MH  - Child
MH  - Humans
MH  - *Physicians
MH  - Prevalence
MH  - Prospective Studies
MH  - Rhinitis, Allergic, Perennial/classification/*diagnosis/*epidemiology/etiology
MH  - Rhinitis, Allergic, Seasonal/classification/*diagnosis/*epidemiology/etiology
MH  - Risk Factors
MH  - Statistics as Topic
MH  - Surveys and Questionnaires
EDAT- 1994/12/01 00:00
MHDA- 1994/12/01 00:01
CRDT- 1994/12/01 00:00
PHST- 1994/12/01 00:00 [pubmed]
PHST- 1994/12/01 00:01 [medline]
PHST- 1994/12/01 00:00 [entrez]
PST - ppublish
SO  - Pediatrics. 1994 Dec;94(6 Pt 1):895-901.