PMID- 7971760
OWN - NLM
STAT- MEDLINE
DCOM- 19941216
LR  - 20190904
IS  - 0197-3851 (Print)
IS  - 0197-3851 (Linking)
VI  - 14
IP  - 7
DP  - 1994 Jul
TI  - Characterization of marker chromosomes by microdissection and fluorescence in 
      situ hybridization.
PG  - 583-8
AB  - We characterized by microdissection and fluorescence in situ hybridization (FISH) 
      two marker chromosomes: (1) a de novo, acrocentric marker chromosome detected in 
      88 per cent of the amniotic fluid cells of one of two physically and 
      developmentally normal twins; and (2) a metacentric marker chromosome present in 
      a phenotypically normal female. Analysis of FISH probes developed from the marker 
      chromosomes indicated that the marker chromosomes in cases 1 and 2 were 
      del(14)(q11) and a derivative chromosome from a Robertsonian translocation, 
      respectively. Microdissection in combination with FISH may prove to be a valuable 
      technique in determining the chromosomal origin of de novo marker chromosomes and 
      unbalanced structural rearrangements detected during prenatal diagnosis.
FAU - Thangavelu, M
AU  - Thangavelu M
AD  - Department of Obstetrics and Gynecology, Northwestern University Medical School, 
      Chicago, IL 60611.
FAU - Pergament, E
AU  - Pergament E
FAU - Espinosa, R 3rd
AU  - Espinosa R 3rd
FAU - Bohlander, S K
AU  - Bohlander SK
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Prenat Diagn
JT  - Prenatal diagnosis
JID - 8106540
RN  - 0 (DNA Probes)
SB  - IM
MH  - Adult
MH  - Amniocentesis
MH  - Base Sequence
MH  - *Chromosome Aberrations
MH  - Chromosomes/*ultrastructure
MH  - Chromosomes, Human, Pair 1
MH  - Chromosomes, Human, Pair 14
MH  - Chromosomes, Human, Pair 9
MH  - DNA Probes
MH  - Diseases in Twins/genetics
MH  - Female
MH  - Gene Deletion
MH  - Humans
MH  - *In Situ Hybridization, Fluorescence
MH  - Molecular Sequence Data
MH  - Polymerase Chain Reaction
MH  - Pregnancy
MH  - *Prenatal Diagnosis
MH  - Ultrasonography, Prenatal
EDAT- 1994/07/01 00:00
MHDA- 2001/03/28 10:01
CRDT- 1994/07/01 00:00
PHST- 1994/07/01 00:00 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1994/07/01 00:00 [entrez]
AID - 10.1002/pd.1970140712 [doi]
PST - ppublish
SO  - Prenat Diagn. 1994 Jul;14(7):583-8. doi: 10.1002/pd.1970140712.