PMID- 7972285
OWN - NLM
STAT- MEDLINE
DCOM- 19941229
LR  - 20190712
IS  - 0091-3057 (Print)
IS  - 0091-3057 (Linking)
VI  - 48
IP  - 4
DP  - 1994 Aug
TI  - The effects of combined prefrontal cortical and hippocampal damage on 
      dopamine-related behaviors in rats.
PG  - 1053-7
AB  - The effects of excitotoxic damage to both the medial prefrontal cortex (MPFC) and 
      the ventral hippocampus (VH) on behaviors related to mesolimbic/nigrostriatal 
      dopamine (DA) transmission were investigated in the rat. Locomotor activity in a 
      novel environment, after injection of saline, and after d-amphetamine was 
      assessed 2 and 4 weeks after ibotenic acid lesion of both MPFC and VH in adult 
      rats. In addition, stereotypic behaviors and locomotion after apomorphine were 
      evaluated 8 weeks after the lesion. Locomotor activity was significantly enhanced 
      in all testing conditions in lesioned rats as compared with sham-operated 
      animals, while oral stereotypic behaviors elicited by apomorphine were attenuated 
      possibly because they were eclipsed by excessive locomotion. These data indicate 
      that coexisting lesions of the MPFC and VH in adult rats produce potent and 
      long-lasting effects on behaviors believed to be dependent primarily on the 
      mesolimbic DA system. The profile of changes resembles more closely that observed 
      after excitotoxic lesions of the VH alone rather than that after separate MPFC 
      lesion.
FAU - Lipska, B K
AU  - Lipska BK
AD  - Clinical Brain Disorders Branch, National Institute of Mental Health, 
      Neuroscience Center at St. Elizabeths, Washington, DC 20032.
FAU - Jaskiw, G E
AU  - Jaskiw GE
FAU - Weinberger, D R
AU  - Weinberger DR
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - N21FAR7B4S (Apomorphine)
RN  - TZ47U051FI (Dextroamphetamine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Animals
MH  - Apomorphine/pharmacology
MH  - Behavior, Animal/*physiology
MH  - Dextroamphetamine/pharmacology
MH  - Dopamine/*physiology
MH  - Hippocampus/*physiology
MH  - Male
MH  - Motor Activity/drug effects
MH  - Prefrontal Cortex/*physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Stereotyped Behavior/drug effects
EDAT- 1994/08/01 00:00
MHDA- 1994/08/01 00:01
CRDT- 1994/08/01 00:00
PHST- 1994/08/01 00:00 [pubmed]
PHST- 1994/08/01 00:01 [medline]
PHST- 1994/08/01 00:00 [entrez]
AID - 0091-3057(94)90220-8 [pii]
AID - 10.1016/0091-3057(94)90220-8 [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 1994 Aug;48(4):1053-7. doi: 
      10.1016/0091-3057(94)90220-8.