PMID- 7976375
OWN - NLM
STAT- MEDLINE
DCOM- 19941208
LR  - 20211203
IS  - 0253-9756 (Print)
IS  - 0253-9756 (Linking)
VI  - 15
IP  - 3
DP  - 1994 May
TI  - Leflunomide inhibits cytokine-induced DNA synthesis of rabbit synovial cells in 
      culture.
PG  - 223-6
AB  - The effects of interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), tumor 
      necrosis factor-alpha (TNF alpha) and granulocyte-macrophage colony-stimulating 
      factor (GM-CSF) on DNA synthesis of rabbit synovial cells were studied. IL-1 beta 
      1000-10,000 U.ml-1, IL-6 10-1000 U.ml-1, TNF alpha 0.5-50 U.ml-1 and GM-CSF 1-100 
      ng.ml-1 concentration-dependently stimulated DNA synthesis in rabbit synovial 
      cells in culture. Leflunomide (LFM) and its metabolite A77 1726 elicited an 
      inhibitory effect on such cytokine-induced DNA synthesis of synovial cells. These 
      results suggested that IL-1 beta, IL-6, TNF alpha and GM-CSF play a key role in 
      the pathogenesis of rheumatoid arthritis. Inhibition of cytokine-induced 
      proliferation of synovial cells by LFM may partially explain its antirheumatic 
      activity.
FAU - Ju, D W
AU  - Ju DW
AD  - Department of Pharmacology, School of Pharmacy, Second Military Medical 
      University, Shanghai, China.
FAU - Zheng, Q Y
AU  - Zheng QY
FAU - Wang, H B
AU  - Wang HB
FAU - Fang, J
AU  - Fang J
LA  - eng
PT  - Journal Article
PL  - China
TA  - Zhongguo Yao Li Xue Bao
JT  - Zhongguo yao li xue bao = Acta pharmacologica Sinica
JID - 8100330
RN  - 0 (Aniline Compounds)
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Crotonates)
RN  - 0 (Cytokines)
RN  - 0 (Hydroxybutyrates)
RN  - 0 (Isoxazoles)
RN  - 0 (Nitriles)
RN  - 0 (Toluidines)
RN  - 1C058IKG3B (teriflunomide)
RN  - 9007-49-2 (DNA)
RN  - G162GK9U4W (Leflunomide)
SB  - IM
MH  - Aniline Compounds/pharmacology
MH  - Animals
MH  - Anti-Inflammatory Agents, Non-Steroidal/*pharmacology
MH  - Cell Division/drug effects
MH  - Cells, Cultured
MH  - Crotonates
MH  - Cytokines/*antagonists & inhibitors
MH  - DNA/*biosynthesis
MH  - Hydroxybutyrates/pharmacology
MH  - Isoxazoles/*pharmacology
MH  - Leflunomide
MH  - Nitriles
MH  - Rabbits
MH  - Synovial Membrane/cytology/*metabolism
MH  - Toluidines
EDAT- 1994/05/01 00:00
MHDA- 1994/05/01 00:01
CRDT- 1994/05/01 00:00
PHST- 1994/05/01 00:00 [pubmed]
PHST- 1994/05/01 00:01 [medline]
PHST- 1994/05/01 00:00 [entrez]
PST - ppublish
SO  - Zhongguo Yao Li Xue Bao. 1994 May;15(3):223-6.