PMID- 7976563
OWN - NLM
STAT- MEDLINE
DCOM- 19941201
LR  - 20191023
VI  - 60
DP  - 1994
TI  - Cytochrome oxidase and hexokinase activities in an infusion edema model with 
      preserved blood flow.
PG  - 268-70
AB  - Despite numerous investigations, the mechanisms underlying the neurological 
      deficits observed in association with interstitial edema remain unclear. A recent 
      study has demonstrated that the cerebral blood flow (CBF) in edematous white 
      matter is unchanged if the blood flow values are corrected for dilution. In 
      contrast, the cerebral glucose metabolism (CMRgl) has been found to be increased. 
      In order to examine the effects of interstitial edema on the oxidative 
      metabolism, we measured the cytochrome oxidase (CYO) activity, a marker of 
      mitochondrial respiration, and the hexokinase (HK) activity, a marker of 
      glycolysis, together with CBF and CMRgl employing the iodoantipyrine and 
      deoxyglucose autoradiography in an infusion edema model in rats. In agreement 
      with the previous study, CBF was not significantly changed in the edematous 
      hemisphere. No significant alterations in CMRgl and HK activity were noted. In 
      contrast, there was a significant decrease in CYO activity in the edematous 
      hemisphere (-17%; p < 0.01), which was correlated to the edema. These findings 
      suggest that interstitial edema causes a decreased mitochondrial respiratory 
      function despite a maintained circulation. This may be explained by postulating a 
      decreased oxygen delivery and/or accumulation of lactate, both of which have been 
      shown to interfere with mitochondrial respiratory function.
FAU - Kawamata, T
AU  - Kawamata T
AD  - Department of Neurological Surgery, Nihon University School of Medicine, Tokyo, 
      Japan.
FAU - Katayama, Y
AU  - Katayama Y
FAU - Kinoshita, K
AU  - Kinoshita K
FAU - Yoshino, A
AU  - Yoshino A
FAU - Hirota, H
AU  - Hirota H
FAU - Tsubokawa, T
AU  - Tsubokawa T
LA  - eng
PT  - Journal Article
PL  - Austria
TA  - Acta Neurochir Suppl (Wien)
JT  - Acta neurochirurgica. Supplementum
JID - 0140560
RN  - 0 (Blood Glucose)
RN  - EC 1.9.3.1 (Electron Transport Complex IV)
RN  - EC 2.7.1.1 (Hexokinase)
SB  - IM
MH  - Animals
MH  - Blood Glucose/metabolism
MH  - Blood-Brain Barrier/physiology
MH  - Brain/*blood supply
MH  - Brain Edema/*physiopathology
MH  - Electron Transport Complex IV/*physiology
MH  - Energy Metabolism/*physiology
MH  - Extracellular Space/physiology
MH  - Glycolysis/physiology
MH  - Hexokinase/*physiology
MH  - Mitochondria/physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Regional Blood Flow/physiology
MH  - Water-Electrolyte Balance/physiology
EDAT- 1994/01/01 00:00
MHDA- 1994/01/01 00:01
CRDT- 1994/01/01 00:00
PHST- 1994/01/01 00:00 [pubmed]
PHST- 1994/01/01 00:01 [medline]
PHST- 1994/01/01 00:00 [entrez]
AID - 10.1007/978-3-7091-9334-1_71 [doi]
PST - ppublish
SO  - Acta Neurochir Suppl (Wien). 1994;60:268-70. doi: 10.1007/978-3-7091-9334-1_71.