PMID- 7977240
OWN - NLM
STAT- MEDLINE
DCOM- 19941229
LR  - 20161123
IS  - 0002-9270 (Print)
IS  - 0002-9270 (Linking)
VI  - 89
IP  - 12
DP  - 1994 Dec
TI  - Endoscopic ultrasound in the evaluation of Barrett's esophagus: a preliminary 
      report.
PG  - 2192-5
AB  - OBJECTIVE: Endoscopic screening of Barrett's esophagus (BE) for dysplasia is 
      imprecise and controversial. Endoscopic ultrasound (EUS) allows a detailed 
      circumferential image of the esophageal wall. Our objective in this study was to 
      assess the utility of EUS for surveillance in Barrett's esophagus. METHODS: 
      Consecutive patients with proven BE undergoing endoscopy were evaluated with EUS. 
      Esophageal wall thickness (EWT) was measured as the distance from the 
      balloon-mucosal interface to the outermost hyperechoic line. EWT was determined 
      as the average of all measurements done every 2-3 cm along the esophagus. 
      Identical measurements were performed in a series of controls. RESULTS: Fifteen 
      patients with BE and 13 control patients were studied. Two patients had focal 
      submucosal thickening on EUS with EWTs of 10 mm and 7 mm. Surgical resection of 
      the esophagus in these two cases with high-grade dysplasia revealed submucosal 
      carcinoma at the area of EUS-documented thickening. The mean EWT of controls 
      measured 2.6 mm, nondysplastic BE measured 3.3 mm, and BE with dysplasia measured 
      4.0 mm. The EWT of both dysplastic and nondysplastic Barrett's was significantly 
      greater than that of the controls (p < 0.02, Student's t test). CONCLUSIONS: 1) 
      As measured by EUS, the esophageal wall is significantly thickened in the 
      columnar-lined portion of Barrett's esophagus. 2) EUS-detected focal thickening 
      may represent submucosal carcinoma in areas of dysplasia and guide early surgery. 
      Thus, EUS may play a role in evaluating the patients with dysplasia in Barrett's 
      esophagus.
FAU - Srivastava, A K
AU  - Srivastava AK
AD  - Department of Medicine, Northwestern University Medical School, Chicago, 
      Illinois.
FAU - Vanagunas, A
AU  - Vanagunas A
FAU - Kamel, P
AU  - Kamel P
FAU - Cooper, R
AU  - Cooper R
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Gastroenterol
JT  - The American journal of gastroenterology
JID - 0421030
SB  - IM
CIN - Am J Gastroenterol. 1995 Jul;90(7):1187. PMID: 7611233
CIN - Am J Gastroenterol. 1996 Feb;91(2):409. PMID: 8607532
MH  - Adult
MH  - Aged
MH  - Barrett Esophagus/*diagnostic imaging/pathology
MH  - *Esophagoscopy
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Ultrasonography/methods
EDAT- 1994/12/01 00:00
MHDA- 1994/12/01 00:01
CRDT- 1994/12/01 00:00
PHST- 1994/12/01 00:00 [pubmed]
PHST- 1994/12/01 00:01 [medline]
PHST- 1994/12/01 00:00 [entrez]
PST - ppublish
SO  - Am J Gastroenterol. 1994 Dec;89(12):2192-5.