PMID- 7978570
OWN - NLM
STAT- MEDLINE
DCOM- 19941201
LR  - 20190717
IS  - 0196-0644 (Print)
IS  - 0196-0644 (Linking)
VI  - 24
IP  - 5
DP  - 1994 Nov
TI  - Electroencephalographic mapping and 99mTc HMPAO single-photon emission computed 
      tomography in carbon monoxide poisoning.
PG  - 947-52
AB  - STUDY OBJECTIVE: To investigate whether topographic analysis of EEG mapping and 
      technetium-99m (99mTc) hexamethylpropylenamine oxide (HMPAO) brain single-photon 
      emission computed tomography (SPECT) can detect cerebral anomalies in the acute 
      phase of carbon monoxide poisoning. DESIGN: Twelve patients aged 18 to 55 years 
      with severe carbon monoxide poisoning and no history of neurologic disorder were 
      evaluated. Either nasal (5 patients) or hyperbaric (7 patients) oxygen therapy 
      was administered. Criteria for hyperbaric oxygen therapy were blood CO of more 
      than 20%, loss of consciousness, pregnancy, or signs of cardiac injury. After 
      oxygen treatment, all patients had a blood CO value of 0% and no patient had 
      persistent acute signs of toxicity. Patients then were investigated by 
      confentional EEG, EEG mapping, and 99mTc HMPAO brain SPECT. These procedures were 
      performed on the day of admission. PARTICIPANTS: After nasal (5 patients) or 
      hyperbaric (7 patients) oxygen therapy was administered, 12 adults with severe 
      carbon monoxide poisoning were evaluated. All studies were performed on the day 
      of admission. MEASUREMENTS: Conventional EEG, EEG mapping, and 99mTc HMPAO brain 
      SPECT. RESULTS: While classic EEG was normal in 9 of 12 patients and showed 
      diffuse anomalies in 3, EEG mapping and 99mTc HMPAO brain SPECT demonstrated 
      unilateral or bilateral regional anomalies in 8 of 12 patients. Anomalies were 
      localized in temporo-parieto-occipital areas, the watershed areas of the major 
      cerebral arteries, or in temporal cortex. CONCLUSION: These preliminary results 
      suggest that EEG mapping and 99mTc HMPAO brain SPECT can be complementary tools 
      to diagnose early regional cerebral anomalies in carbon monoxide-poisoned 
      patients.
FAU - Denays, R
AU  - Denays R
AD  - Department of Neurology, St Pierre Hospital, Free University of Brussels, 
      Belgium.
FAU - Makhoul, E
AU  - Makhoul E
FAU - Dachy, B
AU  - Dachy B
FAU - Tondeur, M
AU  - Tondeur M
FAU - Noel, P
AU  - Noel P
FAU - Ham, H R
AU  - Ham HR
FAU - Mols, P
AU  - Mols P
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Ann Emerg Med
JT  - Annals of emergency medicine
JID - 8002646
RN  - 0 (Organotechnetium Compounds)
RN  - 0 (Oximes)
RN  - 3B744AG22N (Technetium Tc 99m Exametazime)
RN  - 7U1EE4V452 (Carbon Monoxide)
SB  - IM
MH  - Acute Disease
MH  - Adolescent
MH  - Adult
MH  - Brain Diseases/chemically induced/*diagnosis/physiopathology
MH  - Brain Mapping/*methods
MH  - Carbon Monoxide/blood
MH  - Carbon Monoxide Poisoning/blood/*complications/therapy
MH  - Electroencephalography/*methods
MH  - Female
MH  - Humans
MH  - Hyperbaric Oxygenation
MH  - Male
MH  - Middle Aged
MH  - *Organotechnetium Compounds
MH  - *Oximes
MH  - Oxygen Inhalation Therapy
MH  - Sensitivity and Specificity
MH  - Severity of Illness Index
MH  - Technetium Tc 99m Exametazime
MH  - Tomography, Emission-Computed, Single-Photon/*methods
EDAT- 1994/11/01 00:00
MHDA- 1994/11/01 00:01
CRDT- 1994/11/01 00:00
PHST- 1994/11/01 00:00 [pubmed]
PHST- 1994/11/01 00:01 [medline]
PHST- 1994/11/01 00:00 [entrez]
AID - S019606449400212X [pii]
AID - 10.1016/s0196-0644(94)70212-8 [doi]
PST - ppublish
SO  - Ann Emerg Med. 1994 Nov;24(5):947-52. doi: 10.1016/s0196-0644(94)70212-8.