PMID- 7978930
OWN - NLM
STAT- MEDLINE
DCOM- 19941128
LR  - 20190616
IS  - 0077-8923 (Print)
IS  - 0077-8923 (Linking)
VI  - 734
DP  - 1994 Sep 30
TI  - Epidermal growth factor receptor expression and endometrial cancer histotypes.
PG  - 298-305
AB  - Epidermal growth factor receptor (EGF-R) has been implicated in the growth of 
      endometrial cancer. In the present study, immunostaining of EGF-R was 
      investigated in different endometrial cancer histotypes. For this purpose 34 
      surgical samples of primary endometrial carcinoma were studied using monoclonal 
      anti-EGF-R antibody. The endometrial carcinomas were classified according to the 
      International Society of Gynaecological Pathology (I.S.G.P.). EGF-R expression 
      was observed in: 1 of 5 classical endometrioid adenocarcinomas (AE), in 8 of 9 
      endometrial adenocarcinomas with benign squamous metaplasia (AA), and in 3 of 14 
      adenosquamous adenocarcinomas (AS). In mucinous (M) and serous papillary 
      adenocarcinoma (SP) EGF-R immunostaining was not observed. The EGF-R positivity 
      was observed in endometrial cancer with squamous (SQ) differentiation, especially 
      in those with benign SQ metaplasia. These results suggest that EGF-R 
      immunostaining is related to the endometrial cancer histotype regardless of the 
      tumor grade or extent of miometrial invasion.
FAU - Jasonni, V M
AU  - Jasonni VM
AD  - Department of Obstetrics and Gynecology, University of Bologna, S. Orsola General 
      Hospital, Italy.
FAU - Santini, D
AU  - Santini D
FAU - Amadori, A
AU  - Amadori A
FAU - Ceccarelli, C
AU  - Ceccarelli C
FAU - Naldi, S
AU  - Naldi S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ann N Y Acad Sci
JT  - Annals of the New York Academy of Sciences
JID - 7506858
RN  - EC 2.7.10.1 (ErbB Receptors)
SB  - IM
MH  - Adenocarcinoma/metabolism/pathology
MH  - Adenocarcinoma, Mucinous/metabolism/pathology
MH  - Carcinoma, Papillary/metabolism/pathology
MH  - Endometrial Neoplasms/*metabolism/*pathology
MH  - ErbB Receptors/*metabolism
MH  - Female
MH  - Humans
EDAT- 1994/09/30 00:00
MHDA- 1994/09/30 00:01
CRDT- 1994/09/30 00:00
PHST- 1994/09/30 00:00 [pubmed]
PHST- 1994/09/30 00:01 [medline]
PHST- 1994/09/30 00:00 [entrez]
AID - 10.1111/j.1749-6632.1994.tb21759.x [doi]
PST - ppublish
SO  - Ann N Y Acad Sci. 1994 Sep 30;734:298-305. doi: 
      10.1111/j.1749-6632.1994.tb21759.x.