PMID- 7981059
OWN - NLM
STAT- MEDLINE
DCOM- 19950103
LR  - 20190515
IS  - 0007-0920 (Print)
IS  - 1532-1827 (Electronic)
IS  - 0007-0920 (Linking)
VI  - 70
IP  - 6
DP  - 1994 Dec
TI  - Responses to paracrine chemotactic and autocrine chemokinetic factors and lung 
      metastatic capability of mouse RAW117 large-cell lymphoma cells.
PG  - 1089-94
AB  - We studied the cell migration properties of poorly metastatic murine RAW117-P 
      large-cell lymphoma cells, a highly lung metastatic subline (RAW117-L17) and a 
      highly liver metastatic subline (RAW117-H10). L17 cells responded to the 
      serum-free conditioned medium (CM) of mouse lung microvessel endothelial cells 
      (MLEs) and mouse lung fibroblasts (MLFs). The migration of L17 cells was also 
      stimulated by its own CM and, to a lesser extent, by the CM of parental (P) and 
      H10 cells. RAW117-P and -H10 cells responded poorly to all of the CM tested. 
      Chequerboard analyses revealed that the migration-stimulating activities of MLE 
      CM and MLF CM were mainly chemotactic, whereas those of L17, P and H10 CM were 
      chemokinetic. We also analysed the effect of MLE CM and MLF CM in combination 
      with L17, P or H10 CM on cell migration of the RAW117 sublines. The migration of 
      lung metastatic subline L17 cells to MLE or MLF CM was enhanced when L17 CM was 
      also present. This enhancement effect was not seen when P or H10 cells were 
      exposed to MLE or MLF CM plus the CM from P or H10 cells respectively. Thus we 
      found that the chemotactic response of lung metastatic large-cell lymphoma cells 
      to paracrine migration stimulation factors from lung endothelial cells and 
      fibroblasts in concert with an autocrine chemokinetic factor may be involved in 
      RAW117 lung-specific invasion and metastasis.
FAU - Wakabayashi, H
AU  - Wakabayashi H
AD  - Department of Tumor Biology, University of Texas M. D. Anderson Cancer Center, 
      Houston 77030.
FAU - Cavanaugh, P G
AU  - Cavanaugh PG
FAU - Nicolson, G L
AU  - Nicolson GL
LA  - eng
GR  - R35-CA44352/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Br J Cancer
JT  - British journal of cancer
JID - 0370635
RN  - 0 (Chemotactic Factors)
RN  - 0 (Culture Media)
SB  - IM
MH  - Animals
MH  - Cell Movement
MH  - Chemotactic Factors/*physiology
MH  - Culture Media
MH  - In Vitro Techniques
MH  - Lung Neoplasms/secondary
MH  - Lymphoma, Large B-Cell, Diffuse/metabolism/*pathology
MH  - Mice
MH  - Neoplasm Metastasis
MH  - Tumor Cells, Cultured
PMC - PMC2033696
EDAT- 1994/12/01 00:00
MHDA- 1994/12/01 00:01
CRDT- 1994/12/01 00:00
PHST- 1994/12/01 00:00 [pubmed]
PHST- 1994/12/01 00:01 [medline]
PHST- 1994/12/01 00:00 [entrez]
AID - 10.1038/bjc.1994.453 [doi]
PST - ppublish
SO  - Br J Cancer. 1994 Dec;70(6):1089-94. doi: 10.1038/bjc.1994.453.