PMID- 7981945
OWN - NLM
STAT- MEDLINE
DCOM- 19950105
LR  - 20191210
IS  - 0967-3849 (Print)
IS  - 0967-3849 (Linking)
VI  - 2
IP  - 5
DP  - 1994 Sep
TI  - The origin of human chromosome 2 analyzed by comparative chromosome mapping with 
      a DNA microlibrary.
PG  - 405-10
AB  - Fluorescence in situ hybridization (FISH) of microlibraries established from 
      distinct chromosome subregions can test the evolutionary conservation of 
      chromosome bands as well as chromosomal rearrangements that occurred during 
      primate evolution and will help to clarify phylogenetic relationships. We used a 
      DNA library established by microdissection and microcloning from the entire long 
      arm of human chromosome 2 for fluorescence in situ hybridization and comparative 
      mapping of the chromosomes of human, great apes (Pan troglodytes, Pan paniscus, 
      Gorilla gorilla, Pongo pygmaeus) and Old World monkeys (Macaca fuscata and 
      Cercopithecus aethiops). Inversions were found in the pericentric region of the 
      primate chromosome 2p homologs in great apes, and the hybridization pattern 
      demonstrates the known phylogenetically derived telomere fusion in the line that 
      leads to human chromosome 2. The hybridization of the 2q microlibrary to 
      chromosomes of Old World monkeys gave a different pattern from that in the 
      gorilla and the orang-utan, but a pattern similar to that of chimpanzees. This 
      suggests convergence of chromosomal rearrangements in different phylogenetic 
      lines.
FAU - Wienberg, J
AU  - Wienberg J
AD  - Institut fur Anthropologie und Humangenetik, Universitat Munchen, Munich, 
      Germany.
FAU - Jauch, A
AU  - Jauch A
FAU - Ludecke, H J
AU  - Ludecke HJ
FAU - Senger, G
AU  - Senger G
FAU - Horsthemke, B
AU  - Horsthemke B
FAU - Claussen, U
AU  - Claussen U
FAU - Cremer, T
AU  - Cremer T
FAU - Arnold, N
AU  - Arnold N
FAU - Lengauer, C
AU  - Lengauer C
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Chromosome Res
JT  - Chromosome research : an international journal on the molecular, supramolecular 
      and evolutionary aspects of chromosome biology
JID - 9313452
RN  - 0 (DNA, Recombinant)
SB  - IM
MH  - Animals
MH  - Chlorocebus aethiops/genetics
MH  - Chromosome Mapping
MH  - Chromosomes, Human, Pair 2/*ultrastructure
MH  - DNA, Recombinant
MH  - Gene Library
MH  - Gorilla gorilla/genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Macaca/genetics
MH  - Pan troglodytes/genetics
MH  - Phylogeny
MH  - Pongo pygmaeus/genetics
MH  - Primates/*genetics
MH  - Species Specificity
EDAT- 1994/09/01 00:00
MHDA- 1994/09/01 00:01
CRDT- 1994/09/01 00:00
PHST- 1994/09/01 00:00 [pubmed]
PHST- 1994/09/01 00:01 [medline]
PHST- 1994/09/01 00:00 [entrez]
AID - 10.1007/BF01552800 [doi]
PST - ppublish
SO  - Chromosome Res. 1994 Sep;2(5):405-10. doi: 10.1007/BF01552800.