PMID- 7982275
OWN - NLM
STAT- MEDLINE
DCOM- 19950103
LR  - 20190825
IS  - 0305-1870 (Print)
IS  - 0305-1870 (Linking)
VI  - 21
IP  - 6
DP  - 1994 Jun
TI  - The vascular tissue angiotensin I-converting enzyme activity and aortic elastin 
      content in stroke-prone spontaneously hypertensive rats fed fish diet.
PG  - 453-61
AB  - 1. Stroke-prone spontaneously hypertensive rats (SHRSP) were fed a diet with fish 
      meal as the protein source (fish diet) during the progressive stage of 
      hypertension, and its effects on the activity of angiotensin I-converting enzyme 
      (ACE) in serum and vascular tissues and on the aortic elastin content were 
      studied. The effects of the antihypertensive drugs captopril and hydralazine were 
      also studied. 2. Stroke-prone spontaneously hypertensive rats fed the fish diet 
      showed a distinctly lower level (P < 0.05) of serum ACE activity than the control 
      group fed a commercial stock chow. 3. ACE activity was enhanced in the SHRSP 
      which was administered with captopril. 4. Serum ACE activity was similar in the 
      SHRSP receiving the hydralazine treatment and the control group. 5. The thoracic 
      aorta ACE activity was lowered more (P < 0.05) in the fish diet group and the 
      captopril-treated group than in the control group. In the hydralazine-treated 
      group however, the activity was similar to the control group. 6. The ratio of 
      aorta weight to bodyweight was significantly lower (P < 0.05) in the fish diet 
      group and the captopril-treated group than in the control group, but there was no 
      difference in the hydralazine group. Higher levels of aortic elastin were 
      observed in the drug-treated groups (P < 0.05). 7. No differences were seen 
      between the fish diet and captopril-treated groups by electron-microscopy. 8. The 
      results suggest that suppression of hypertrophy and ameliorations of reduction in 
      elasticity of the vascular wall in the SHRSP fed a fish diet were due to 
      inhibition of vascular tissue ACE activity.
FAU - Murakami, T
AU  - Murakami T
AD  - Department of Food Science and Nutrition, Faculty of Agriculture, Kinki 
      University, Nara, Japan.
FAU - Soga, M
AU  - Soga M
FAU - Mitsunaga, T
AU  - Mitsunaga T
FAU - Yoshizumi, H
AU  - Yoshizumi H
FAU - Ito, H
AU  - Ito H
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Clin Exp Pharmacol Physiol
JT  - Clinical and experimental pharmacology & physiology
JID - 0425076
RN  - 26NAK24LS8 (Hydralazine)
RN  - 9007-58-3 (Elastin)
RN  - EC 3.4.15.1 (Peptidyl-Dipeptidase A)
SB  - IM
MH  - Animals
MH  - Aorta, Thoracic/drug effects/metabolism
MH  - *Diet
MH  - Elastin/*metabolism
MH  - *Fish Products
MH  - Hydralazine/pharmacology
MH  - Male
MH  - Microscopy, Electron
MH  - Myocardium/enzymology/*metabolism
MH  - Organ Size/drug effects/physiology
MH  - Peptidyl-Dipeptidase A/blood/*metabolism
MH  - Rats
MH  - Rats, Inbred SHR
EDAT- 1994/06/01 00:00
MHDA- 1994/06/01 00:01
CRDT- 1994/06/01 00:00
PHST- 1994/06/01 00:00 [pubmed]
PHST- 1994/06/01 00:01 [medline]
PHST- 1994/06/01 00:00 [entrez]
AID - 10.1111/j.1440-1681.1994.tb02541.x [doi]
PST - ppublish
SO  - Clin Exp Pharmacol Physiol. 1994 Jun;21(6):453-61. doi: 
      10.1111/j.1440-1681.1994.tb02541.x.