PMID- 7984261
OWN - NLM
STAT- MEDLINE
DCOM- 19950103
LR  - 20190920
IS  - 0161-6412 (Print)
IS  - 0161-6412 (Linking)
VI  - 16
IP  - 4
DP  - 1994 Aug
TI  - Local cerebral blood flow and glucose metabolism in chronic focal ischaemia of 
      stroke-prone spontaneously hypertensive rats.
PG  - 289-96
AB  - The relationship between local cerebral blood flow (ICBF) and local cerebral 
      glucose metabolism (ICGU) at the chronic stage of focal cerebral ischaemia was 
      assessed in young stroke-prone spontaneously hypertensive rats (SHRSP) following 
      occlusion of the distal middle cerebral artery (MCA). On day 7 following this 
      occlusion, ICBF and ICGU were measured by autoradiographic methods using 
      14C-iodoantipyrine and 14C-2-deoxyglucose (2DG), respectively. The infarct was 
      limited to the ipsilateral cerebral cortex. A narrow band of increased uptake of 
      14C-2DG was observed in the border zone at the periphery of infarcted areas. The 
      ICBF in the ischaemic cortex revealed a graded reduction from the ischaemic 
      centre to the surrounding tissues. A significant reduction in ICGU coupled to CBF 
      was also observed in 4 of 13 selected noninfarcted regions ipsilateral to the MCA 
      occlusion. The ischaemic regions had a significant increase in water content. The 
      region with ischaemic oedema was limited to a narrow area compared with the 
      findings regarding ICBF and ICGU. The SHRSP strain has more severe cerebral 
      ischaemia, oedema formation, and metabolic derangement at the chronic stage of 
      focal ischaemia, compared to normo-tensive animals.
FAU - Shima, K
AU  - Shima K
AD  - Department of Neurosurgery, National Defense Medical College, Tokorozawa, Japan.
FAU - Umezawa, H
AU  - Umezawa H
FAU - Chigasaki, H
AU  - Chigasaki H
FAU - Okuyama, S
AU  - Okuyama S
FAU - Araki, H
AU  - Araki H
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Neurol Res
JT  - Neurological research
JID - 7905298
RN  - 0 (Carbon Radioisotopes)
RN  - 142M471B3J (Carbon Dioxide)
RN  - 9G2MP84A8W (Deoxyglucose)
RN  - IY9XDZ35W2 (Glucose)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Animals
MH  - Autoradiography
MH  - Blood Pressure
MH  - Brain/blood supply/metabolism/*physiopathology
MH  - Carbon Dioxide/blood
MH  - Carbon Radioisotopes
MH  - *Cerebrovascular Circulation
MH  - Cerebrovascular Disorders
MH  - Deoxyglucose/metabolism
MH  - Glucose/*metabolism
MH  - Ischemic Attack, Transient/metabolism/*physiopathology
MH  - Male
MH  - Organ Specificity
MH  - Oxygen/blood
MH  - Partial Pressure
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Rats, Inbred WKY
MH  - Reference Values
MH  - Regional Blood Flow
EDAT- 1994/08/01 00:00
MHDA- 1994/08/01 00:01
CRDT- 1994/08/01 00:00
PHST- 1994/08/01 00:00 [pubmed]
PHST- 1994/08/01 00:01 [medline]
PHST- 1994/08/01 00:00 [entrez]
AID - 10.1080/01616412.1994.11740242 [doi]
PST - ppublish
SO  - Neurol Res. 1994 Aug;16(4):289-96. doi: 10.1080/01616412.1994.11740242.