PMID- 7985276
OWN - NLM
STAT- MEDLINE
DCOM- 19950103
LR  - 20061115
IS  - 0041-5782 (Print)
IS  - 0041-5782 (Linking)
VI  - 156
IP  - 40
DP  - 1994 Oct 3
TI  - [Low molecular weight heparin versus unfractionated heparin in the treatment of 
      deep venous thrombosis--a meta-analysis].
PG  - 5844-9
AB  - A review based on 17 randomised studies on low molecular weight heparin (LMWH) 
      versus unfractionated heparin (UFH) in the treatment of objectively verified deep 
      venous thrombosis (DVT) is presented. Long-term treatment with LMWH was compared 
      with long-term UFH in two studies and with warfarin in one study. In the rest of 
      the studies LMWH and UFH were used during initiation of oral anticoagulant 
      therapy, and these studies were included in a meta-analysis. The relative risk of 
      progression of DVT during LMWH treatment compared with UFH was 0.63 (95% 
      confidence interval: 0.39-1.00) and the relative risk of major bleeding was 0.41 
      (95% confidence interval: 0.24-0.70). There was no significant difference in the 
      reduction of Marder score during treatment (LMWH 5.0 versus UFH 3.8) or in the 
      frequency of new symptomatic, scintigraphically or angiographically verified 
      pulmonary embolism (LMWH 0.6% versus UFH 1.1%). The frequency of complications 
      seemed independent of whether LMWH was administered once or twice daily. 
      Monitoring of LMWH treatment is not considered necessary but determination of 
      anti-factor Xa in plasma is recommended if bleeding occurs during treatment with 
      LMWH.
FAU - Nielsen, J D
AU  - Nielsen JD
AD  - Hjertemedicinsk afdeling Y., Bispebjerg Hospital, Kobenhavn.
FAU - Landorph, A
AU  - Landorph A
LA  - dan
PT  - Clinical Trial
PT  - Comparative Study
PT  - English Abstract
PT  - Journal Article
PT  - Meta-Analysis
PT  - Randomized Controlled Trial
TT  - Lavmolekylaert heparin versus ufraktioneret heparin ved behandling af dyb 
      venetrombose--en metaanalyse.
PL  - Denmark
TA  - Ugeskr Laeger
JT  - Ugeskrift for laeger
JID - 0141730
RN  - 0 (Heparin, Low-Molecular-Weight)
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Heparin/*administration & dosage/adverse effects
MH  - Heparin, Low-Molecular-Weight/*administration & dosage/adverse effects
MH  - Humans
MH  - Thrombophlebitis/*drug therapy
EDAT- 1994/10/03 00:00
MHDA- 1994/10/03 00:01
CRDT- 1994/10/03 00:00
PHST- 1994/10/03 00:00 [pubmed]
PHST- 1994/10/03 00:01 [medline]
PHST- 1994/10/03 00:00 [entrez]
PST - ppublish
SO  - Ugeskr Laeger. 1994 Oct 3;156(40):5844-9.