PMID- 7987809
OWN - NLM
STAT- MEDLINE
DCOM- 19950110
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 78
IP  - 1
DP  - 1994 Nov
TI  - Chromosome derived from translocation(1;17) retains alphoid sequences of both 
      chromosomes involved.
PG  - 7-9
AB  - Examining a bone marrow (BM) karyotype of a patient with a refractory anemia with 
      excess of blasts (RAEB), we detected a clone with an unbalanced 
      translocation(1;17), resulting in monosomy of 17p and trisomy of 1q. Using 
      fluorescence in situ hybridization (FISH) technique with alpha-satellite DNA 
      probes specific for chromosomes 1 and 17, we observed that the chromosome derived 
      from the translocation shows hybridization signals for both the centromeres of 
      chromosomes 1 and 17. This finding suggests that the breakpoints of the two 
      autosomes involved in the rearrangement occurred in the primary constriction. The 
      case confirms the ability of ISH analysis to detect structural rearrangements in 
      cancer cytogenetics.
FAU - Fugazza, G
AU  - Fugazza G
AD  - Department of Internal Medicine, University of Genova, Italy.
FAU - Bruzzone, R
AU  - Bruzzone R
FAU - Sessarego, M
AU  - Sessarego M
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - 0 (DNA, Satellite)
SB  - IM
MH  - Adult
MH  - Anemia, Refractory, with Excess of Blasts/*genetics
MH  - *Chromosomes, Human, Pair 1
MH  - *Chromosomes, Human, Pair 17
MH  - DNA, Satellite/analysis
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - *Translocation, Genetic
EDAT- 1994/11/01 00:00
MHDA- 1994/11/01 00:01
CRDT- 1994/11/01 00:00
PHST- 1994/11/01 00:00 [pubmed]
PHST- 1994/11/01 00:01 [medline]
PHST- 1994/11/01 00:00 [entrez]
AID - 0165-4608(94)90038-8 [pii]
AID - 10.1016/0165-4608(94)90038-8 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1994 Nov;78(1):7-9. doi: 10.1016/0165-4608(94)90038-8.