PMID- 7988267
OWN - NLM
STAT- MEDLINE
DCOM- 19950112
LR  - 20071115
IS  - 0012-3692 (Print)
IS  - 0012-3692 (Linking)
VI  - 106
IP  - 6 Suppl
DP  - 1994 Dec
TI  - Tumor suppressor and immediate early transcription factor genes in non-small cell 
      lung cancer.
PG  - 372S-376S
AB  - Non-small lung cancer (NSCLC) is a disease that exhibits multiple genetic 
      lesions. Lung Cancer Study Group (LCSG) 871 was designed to analyze this group of 
      malignancies for alterations in growth factors and/or their receptors, oncogenes, 
      tumor suppressor genes, and immediate early transcription factor genes. 
      Immunohistochemical analysis showed that 32% of evaluable cases studied contained 
      absent or abnormal Rb expression. Sequence analysis of the p53 gene revealed that 
      58% of these cancers contained structural alterations of this gene, whereas only 
      45% of these cases overexpressed p53 by immunohistochemical analysis. Finally, 
      both Northern blot and immunohistochemical analysis showed that these tumors 
      exhibited changes in the mRNA and protein expression levels respectively of the 
      immediate early transcription factor genes c-fos, c-jun, and EGR, in that less 
      expression of these genes was evident in the tumors compared with adjacent normal 
      tissue. Understanding both the biologic and molecular significance of these 
      findings may allow us to explore novel modalities for treatment of this disease.
FAU - Levin, W J
AU  - Levin WJ
AD  - Department of Medicine, UCLA School of Medicine.
FAU - Casey, G
AU  - Casey G
FAU - Ramos, J C
AU  - Ramos JC
FAU - Arboleda, M J
AU  - Arboleda MJ
FAU - Reissmann, P T
AU  - Reissmann PT
FAU - Slamon, D J
AU  - Slamon DJ
LA  - eng
GR  - R01CA36829/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - Chest
JT  - Chest
JID - 0231335
RN  - 0 (RNA Probes)
SB  - IM
GS  - Rb
GS  - fos
GS  - jun
GS  - myb
GS  - myc
GS  - p53
MH  - Carcinoma, Non-Small-Cell Lung/*genetics
MH  - Clinical Trials as Topic
MH  - Gene Expression
MH  - *Genes, Tumor Suppressor
MH  - Genes, fos/genetics
MH  - Genes, jun/genetics
MH  - Genes, p53/genetics
MH  - Humans
MH  - Immunohistochemistry
MH  - Lung Neoplasms/*genetics
MH  - Multicenter Studies as Topic
MH  - Mutation
MH  - RNA Probes
MH  - Randomized Controlled Trials as Topic
MH  - Sequence Analysis, DNA
MH  - *Transcription, Genetic
RF  - 27
EDAT- 1994/12/01 00:00
MHDA- 1994/12/01 00:01
CRDT- 1994/12/01 00:00
PHST- 1994/12/01 00:00 [pubmed]
PHST- 1994/12/01 00:01 [medline]
PHST- 1994/12/01 00:00 [entrez]
AID - S0012-3692(15)45360-7 [pii]
PST - ppublish
SO  - Chest. 1994 Dec;106(6 Suppl):372S-376S.