PMID- 7988603
OWN - NLM
STAT- MEDLINE
DCOM- 19950109
LR  - 20190512
IS  - 0195-668X (Print)
IS  - 0195-668X (Linking)
VI  - 15
IP  - 8
DP  - 1994 Aug
TI  - Reversal of ischaemic systolic and diastolic left ventricular dysfunction by 
      successful coronary angioplasty in patients with non-Q wave anterior myocardial 
      infarction.
PG  - 1106-12
AB  - The effect of PTCA on global and regional left ventricular systolic function, 
      isovolumic relaxation, chamber and muscle stiffness were studied in 30 patients 
      with angina pectoris, previous non-Q wave anterior myocardial infarction (AMI) 
      and significant stenosis of the left anterior descending coronary artery (LAD). 
      In 11 of the 30 patients the condition was stable, but it was unstable in 19. 
      Left ventricular angiograms were obtained before and 4.85 +/- 3.67 months after 
      PTCA. The RAO was in the 30 degree projection, with the silhouette of the left 
      ventricle sliced into 90 regions; changes in left ventricular volume, pressure 
      and anterior wall thickness during the full cardiac cycle, together with dp/dt 
      were demonstrated. After PTCA, global ejection fraction increased from 68.77 +/- 
      5.96% to 76.57 +/- 3.18%, P < 0.001. Impaired contractility was found in 29/90 
      (32.2%) regions before PTCA and in 5/90 (5.6%) after PTCA, P < 0.001. The time 
      constant of the isovolumic pressure fall decreased after PTCA (52.56 +/- 17.40 ms 
      vs 39.61 +/- 11.26 ms, P < 0.01). Elastic chamber stiffness coefficient decreased 
      (0.022 +/- 0.003 vs 0.008 +/- 0.004, P < 0.001) and peak rate of left ventricular 
      filling increased (319.0 +/- 107.9 ml.min-1 vs 396.8 +/- 201.4 ml.min-1, P < 
      0.05) after PTCA. The muscle stiffness coefficient was within normal values 
      before and did not change after PTCA. The study findings show that in patients 
      with persistent angina pectoris after non-Q wave AMI, complex systolic and 
      diastolic ischaemic dysfunction occurs. This dysfunction can be reversed after 
      successful PTCA of LAD.
FAU - Witkowski, A
AU  - Witkowski A
AD  - General Cardiology and Haemodynamics Department, Institute of Cardiology, Warsaw, 
      Poland.
FAU - Ruzyllo, W
AU  - Ruzyllo W
FAU - Gorecka, B
AU  - Gorecka B
FAU - Chmielak, Z
AU  - Chmielak Z
FAU - Jodkowski, J
AU  - Jodkowski J
FAU - Dabrowski, M
AU  - Dabrowski M
FAU - Woroszylska, M
AU  - Woroszylska M
FAU - Debski, A
AU  - Debski A
FAU - Demkow, M
AU  - Demkow M
FAU - Ciszewski, A
AU  - Ciszewski A
AU  - et al.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Eur Heart J
JT  - European heart journal
JID - 8006263
SB  - IM
MH  - Adult
MH  - Angina Pectoris/physiopathology/therapy
MH  - *Angioplasty, Balloon, Coronary
MH  - Diastole/*physiology
MH  - Electrocardiography
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Rate/physiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Contraction/physiology
MH  - Myocardial Infarction/physiopathology/*therapy
MH  - Myocardial Ischemia/physiopathology/*therapy
MH  - Prospective Studies
MH  - Stroke Volume/physiology
MH  - Systole/*physiology
MH  - Ventricular Dysfunction, Left/physiopathology/*therapy
MH  - Ventricular Function, Left/physiology
EDAT- 1994/08/01 00:00
MHDA- 1994/08/01 00:01
CRDT- 1994/08/01 00:00
PHST- 1994/08/01 00:00 [pubmed]
PHST- 1994/08/01 00:01 [medline]
PHST- 1994/08/01 00:00 [entrez]
AID - 10.1093/oxfordjournals.eurheartj.a060635 [doi]
PST - ppublish
SO  - Eur Heart J. 1994 Aug;15(8):1106-12. doi: 
      10.1093/oxfordjournals.eurheartj.a060635.